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Transaldolase 1

From Wikipedia, the free encyclopedia
TALDO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTALDO1, TAL, TAL-H, TALDOR, TALH, transaldolase 1
External IDsOMIM: 602063; MGI: 1274789; HomoloGene: 4916; GeneCards: TALDO1; OMA:TALDO1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006755

NM_011528

RefSeq (protein)

NP_006746

NP_035658

Location (UCSC)Chr 11: 0.75 – 0.77 MbChr 7: 140.97 – 140.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transaldolase 1 is a protein that in humans is encoded by the TALDO1 gene. [5]

Function

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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177156Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025503Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Transaldolase 1". Retrieved 2017-10-19.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.