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Small nucleolar rna host gene 1

From Wikipedia, the free encyclopedia
SNHG1
Identifiers
AliasesSNHG1, LINC00057, NCRNA00057, U22HG, UHG, small nucleolar RNA host gene 1, lncRNA16
External IDsOMIM: 603222; GeneCards: SNHG1; OMA:SNHG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Small nucleolar RNA host gene 1 is a non-protein coding RNA that in humans is encoded by the SNHG1 gene. [2][3]

Function

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This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017].

References

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  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Entrez Gene: Small nucleolar RNA host gene 1". Retrieved 2018-09-04.
  3. ^ Tycowski, KT; Shu, MD; Steitz, JA (1 February 1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. Bibcode:1996Natur.379..464T. doi:10.1038/379464a0. PMID 8559254. S2CID 4319950.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.