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SESN3

From Wikipedia, the free encyclopedia
SESN3
Identifiers
AliasesSESN3, SEST3, sestrin 3
External IDsOMIM: 607768; MGI: 1922997; HomoloGene: 14386; GeneCards: SESN3; OMA:SESN3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271594
NM_144665

NM_030261

RefSeq (protein)

NP_001258523
NP_653266

NP_084537

Location (UCSC)Chr 11: 95.17 – 95.23 MbChr 9: 14.19 – 14.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sestrin 3 is a protein that in humans is encoded by the SESN3 gene. [5]

Function

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This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149212Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032009Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.