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MCM3AP

From Wikipedia, the free encyclopedia
MCM3AP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMCM3AP, GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein, PNRIID
External IDsOMIM: 603294; MGI: 1930089; HomoloGene: 2902; GeneCards: MCM3AP; OMA:MCM3AP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003906

NM_019434

RefSeq (protein)

NP_003897

NP_062307

Location (UCSC)Chr 21: 46.24 – 46.29 MbChr 10: 76.3 – 76.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.[5][6]

Function

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The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.[6]

Interactions

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MCM3AP has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160294Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001150Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.
  6. ^ a b "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein".
  7. ^ Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi:10.1074/jbc.C200442200. PMID 12226073.
  8. ^ Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.
  9. ^ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Germinal-center associated nuclear protein (MCM3AP)