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MAGEA5

From Wikipedia, the free encyclopedia
MAGEA5P
Identifiers
AliasesMAGEA5P, CT1.5, MAGE5, MAGEA4, MAGE family member A5, MAGE family member A5, pseudogene, MAGEA5
External IDsOMIM: 300340; HomoloGene: 130448; GeneCards: MAGEA5P; OMA:MAGEA5P - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021049

n/a

RefSeq (protein)

NP_066387

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Melanoma antigen family A, 5 is a protein in humans that is encoded by the MAGEA5 gene. [2]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011].

References

[edit]
  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Entrez Gene: Melanoma antigen family A, 5". Retrieved 2013-02-16.

Further reading

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