Jump to content

Indeterminate cell histiocytosis

From Wikipedia, the free encyclopedia
Indeterminate cell histiocytosis
Other namesIndeterminate dendritic cell tumor
SpecialtyDermatology

Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics.[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.[2]

Signs and symptoms

[edit]

Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission.[3]

Causes

[edit]

Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.[6]

Treatment

[edit]

Treatment include 5% 5-fluorouracil cream, topical pure coal tar, electron beam therapy, phototherapy, and total excision.[7][8]

See also

[edit]

References

[edit]
  1. ^ Vener, C.; Soligo, D.; Berti, E.; Gianelli, U.; Servida, F.; Ceretti, E.; Caputo, R.; Passoni, E.; Lambertenghi Deliliers, G. (2007). "Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia". British Journal of Dermatology. 156 (6). Oxford University Press (OUP): 1357–1361. doi:10.1111/j.1365-2133.2007.07880.x. ISSN 0007-0963. PMID 17459045. S2CID 41005413.
  2. ^ WOOD, GARY S.; HU, CHUNG-HONG; BECKSTEAD, JAY H.; TURNER, RODERICK R.; WINKELMANN, R. K. (1985). "The Indeterminate Cell Proliferative Disorder: Report of a Case Manifesting as an Unusual Cutaneous Histiocytosis". The Journal of Dermatologic Surgery and Oncology. 11 (11). Wiley: 1111–1119. doi:10.1111/j.1524-4725.1985.tb01399.x. ISSN 0148-0812. PMID 3902927.
  3. ^ Zerbini, Maria Claudia Nogueira; Sotto, Mirian Nacagami; Campos, Fernando Peixoto Ferraz de; Abdo, Andre Neder Ramires; Pereira, Juliana; Sanches, José Antônio; Martins, Jade Cury (2016). "Indeterminate cell histiocytosis successfully treated with phototherapy". Autopsy and Case Reports. 6 (2). Editora Cubo: 33–38. doi:10.4322/acr.2016.038. ISSN 2236-1960. PMC 4982782. PMID 27547741.
  4. ^ Hashimoto, Ken; Fujiwara, Keiko; Punwaney, Juanita; DiGregorio, Fiorino; Bostrom, Paul; El-Hoshy, Khaled; Aronson, Peter J.; Schoenfeld, Robert J. (2000). "Post-Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells". The Journal of Dermatology. 27 (3). Wiley: 181–194. doi:10.1111/j.1346-8138.2000.tb02148.x. ISSN 0385-2407. PMID 10774146. S2CID 23463988.
  5. ^ Mo, Xianglan; Guo, Wenwen; Ye, Hongtao (2015). "Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite". Medicine. 94 (34). Ovid Technologies (Wolters Kluwer Health): e1443. doi:10.1097/md.0000000000001443. ISSN 0025-7974. PMC 4602924. PMID 26313805.
  6. ^ Brown, Ryanne A.; Kwong, Bernice Y.; McCalmont, Timothy H.; Ragsdale, Bruce; Ma, Lisa; Cheung, Christine; Rieger, Kerri E.; Arber, Daniel A.; Kim, Jinah (November 12, 2015). "ETV3-NCOA2 in indeterminate cell histiocytosis: clonal translocation supports sui generis". Blood. 126 (20). American Society of Hematology: 2344–2345. doi:10.1182/blood-2015-07-655530. ISSN 0006-4971. PMID 26438513.
  7. ^ Miracco, Clelia; Raffaelli, Miranda; de Santi, Maria; Margherita, M.S; Fimiani, Michele; Tosi, Piero (February 1988). "Solitary cutaneous reticulum cell tumor. Enzyme-immunohistochemical and electron-microscopic analogies with IDRC sarcoma". The American Journal of Dermatopathology. 10 (1): 47–53. doi:10.1097/00000372-198802000-00006. PMID 2845833. Retrieved 24 January 2024.
  8. ^ Berti, Emilio (August 1, 1988). "Unusual Cutaneous Histiocytosis Expressing an Intermediate Immunophenotype Between Langerhans' Cells and Dermal Macrophages". Archives of Dermatology. 124 (8). American Medical Association (AMA): 1250. doi:10.1001/archderm.1988.01670080062020. ISSN 0003-987X. PMID 3401031.

Further reading

[edit]
[edit]