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GSK3A

From Wikipedia, the free encyclopedia
GSK3A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSK3A, Gsk3a, 2700086H06Rik, glycogen synthase kinase 3 alpha
External IDsOMIM: 606784; MGI: 2152453; HomoloGene: 88581; GeneCards: GSK3A; OMA:GSK3A - orthologs
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019884

NM_001031667

RefSeq (protein)

NP_063937

NP_001026837

Location (UCSC)Chr 19: 42.23 – 42.24 MbChr 7: 24.93 – 24.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.[5]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.[6][7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105723Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057177Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Oct 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome. 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID 9809441.
  6. ^ Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
  7. ^ "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha".