Jump to content

Bradykinin receptor B1

From Wikipedia, the free encyclopedia
BDKRB1
Identifiers
AliasesBDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, Bradykinin receptor B1
External IDsOMIM: 600337; MGI: 88144; HomoloGene: 570; GeneCards: BDKRB1; OMA:BDKRB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000710
NM_001386007

NM_007539

RefSeq (protein)

NP_000701

NP_031565

Location (UCSC)Chr 14: 96.26 – 96.27 MbChr 12: 105.57 – 105.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[5]

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[6]

Antagonists

[edit]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041347Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: BDKRB1 bradykinin receptor B1".
  6. ^ Seabrook GR, Bowery BJ, Hill RG (1995). "Bradykinin receptors in mouse and rat isolated superior cervical ganglia". Br J Pharmacol. 115 (2): 368–72. doi:10.1111/j.1476-5381.1995.tb15887.x. PMC 1908315. PMID 7670739.
[edit]

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.