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ARMCX6

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ARMCX6
Identifiers
AliasesARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6
External IDsMGI: 2147993; HomoloGene: 10373; GeneCards: ARMCX6; OMA:ARMCX6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001009584
NM_001184768
NM_019007

NM_001007578

RefSeq (protein)

NP_001009584
NP_001171697
NP_061880

NP_001007579

Location (UCSC)Chr X: 101.62 – 101.62 MbChr X: 133.65 – 133.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.[5]

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

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     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

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ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

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taxonomic name common name NCBI entry Percentage of sequence similarity Length (AAs) comments
Homo sapiens Human [1] 100% 300 armadillo repeat containing X-linked 6
Macaca mulatta Rhesus monkey [2] 97.0% 300 PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballus Horse [3] 90.0% 300 PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio rerio zebrafish [4] 84.0% 301 Similar to RIKEN cDNA 0610039K22
Mus musculus House Mouse [5] 97.7% 393 armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos taurus cow [6] 83.0% 301 armadillo repeat containing, X-linked 6
Mus musculus Mouse [7] 82.0% 301 armadillo repeat containing, X-linked 6
Takifugu rubripes Tetradontoidea [8] 66.0% 818 aryl hydrocarbon receptor 2C
Caenorhabditis elegans C. elegans [9] 50.0% 332 Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiae Yeast [10] 70.0% 910 Hul5p
Gallus gallus Chicken [11] 52.0% 317 PREDICTED: hypothetical protein

Secondary Structure

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The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.[6][7]

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++

Cyanase segment having identity with ARMCX6.

Expression

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Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.[8][9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198960Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050394Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: armadillo repeat containing".
  6. ^ SDSC Biology Workbench 2.0
  7. ^ "CBlast service is retiring".
  8. ^ EST Profile Viewer- Human
  9. ^ EST Profile Viewer- Mouse
  10. ^ Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. Bibcode:2004PNAS..101.6062S. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.
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Further reading

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