With an CDMO expertise since 1975, Glatt Pharmaceutical Services offers solutions for formulation and process development of solid dosage forms. Scale up, Clinical trials materials and commercial manufacturing from our sites in Binzen/Germany and Ramsey/New Jersey.
We offer clinical supplies management as well as storage and distribution of commercial products from our distribution hub in Lörrach/Germany.
Great exchanges during #CRS2024 with Adèle Rakotonirina, PhD including the transition from University to Industry. Surely a lot to learn from both perspectives to improve communication and knowledge and make such transitions easier.
Adèle Rakotonirina obtained her PhD in Pharmaceutical Sciences in June 2023 at the University of Geneva. She worked on a novel oral formulation for fecal microbiota transplantation. During her PhD, she has discovered a passion for science communication by participating to "Ma thèse en 180 secondes" and wanted to work in a role that has this aspect.
She has now transitioned to the industry as a Junior Business Development Manager. She uses her scientific knowledge and communication skills every day to connect with all kinds of scientists with innovative projects.
She participated in the takeover at CRS 2024 to talk about her transition to the industry and presented the different career possibilities after university.
✔Making your solid oral formulations projects come true - CDMO | Business Development | 💊 Formulation scientist, Drug Delivery | 🎙 Science communicator
Kicked off the first day of Controlled Release Society (CRS) #CRS2024 in Bologna!
The workshop about Oral Drug Delivery organized by MeltPrep was very insightful with talks reminding us of the basics of oral formulations and promoting collaborations from actors in academia and industries to give the best solutions to patients.
It was exciting to learn about innovative technologies, modeling programs and the effect of food intake on drug bioavailability, among others!
Looking forward to the next few days connecting and reconnecting with you! If you see me at #CRS2024 please come and say hi 😊
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#drugdelivery#formulation#pharmaceutical#technology
𝗦𝗰𝗮𝗹𝗲 𝘂𝗽 𝗼𝗳 𝗮 𝗙𝗹𝘂𝗶𝗱𝗯𝗲𝗱 𝗚𝗿𝗮𝗻𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗣𝗿𝗼𝗰𝗲𝘀𝘀?
Have look at "A linear scale-up approach to fluid bed granulation"
by Victor Emenike, Dr. Ivonne Kulla, Martin Maus, Andrea Staab and Daniela Schröder and learn more about the "Maus factor" too.
Fluid bed granulation (FBG) is used extensively in the pharmaceutical industry and it is known to be a complex process, because the final product quality of the FBG process is determined by a complex interplay between the process parameters, fluid dynamics, and material properties. Due to this complexity, the FBG process is inherently nonlinear and as such difficult to scale-up.
The field of chemical engineering has shown that complex nonlinear processes can be assumed to be linear under limiting conditions. We leverage this idea and present a linear scale-up approach (LiSA) to the FBG process. We derive the key LiSA equation from first principles, and then use it in combination with the similarity principle for scale-up purposes.
Furthermore, we present a novel regression-based LiSA. The regression-based LiSA is founded on the hypothesis that there is a linear relationship between the moisture content and a scaling parameter called the Maus factor. This hypothesis is based on our experience and it is shown to be plausible due to high 𝑅2 values ranging from 0.86 to 0.98. Moreover, we successfully demonstrate that LiSA is effective under typical industrial process settings by applying it to two different formulations during pharmaceutical drug product development. Continue reading here: https://lnkd.in/e3MacRVS.
Questions? Just get in touch with us!
#scaleup#fluidbed#granulationGlatt Group
𝗟𝗲𝘁´𝘀 𝗺𝗲𝗲𝘁 & 𝘁𝗮𝗹𝗸 𝗮𝘁 𝗖𝗥𝗦 𝟮𝟬𝟮𝟰 𝗶𝗻 𝗕𝗼𝗹𝗼𝗴𝗻𝗮
For us it is all about controlled release of orald solids. Adèle Rakotonirina, PhD will be in Bologna and happy to exchange with you to all topics related to controlled drug delivery and solubility enhancements.
#ods#pharmaceutics#drugdelivery Controlled Release Society (CRS)
𝗧𝗿𝗮𝗰𝗶𝗻𝗴 𝘁𝗵𝗲 𝗘𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗙𝘂𝘁𝘂𝗿𝗲 𝗼𝗳 𝗖𝗮𝗽𝘀𝘂𝗹𝗲 𝗠𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴
We just came across this podcast episode on capsules by Ljiljana Palangetic and Bram Baert from Lonza, to delve into the intricacies of capsule manufacturing and the evolution of drug delivery technologies. Get the full podcast here: https://lnkd.in/d95tpBw8
As a CDMO we are heavily involved in capsule filling for all phases of the drug product development and have installed versatile equipment setups from Harro Höfliger to fulfill your needs. Happy to tell you more about our possibilities to bring your drug into a capsule or support you clinical supply needs.
#capsules#pharmaceuticals
𝟳𝟬 𝘆𝗲𝗮𝗿𝘀 𝗼𝗳 𝗚𝗹𝗮𝘁𝘁 🥂
and 49 years of CDMO services within the Glatt Group. Our Ramsey site started in 1975 applying Glatt technologies and processes to develop oral solid dosage forms. ini 1998 the services started also in Binzen, Germany. Today we are way further in our solutions for drug product development and manufacturing and happy to celebrate this company milestone!
We are celebrating a very special anniversary this year: 70 years of Glatt! Since the company was founded in 1954, we have always been committed to cohesion, innovation, and quality. As a pioneer in fluidized bed technology, we are particularly proud today that our internationally active family business is now in its third generation.
Our heartfelt thanks go to all our employees, partners and customers who have supported us along the way and will continue in the future.
We look forward to the next 70 years of innovation and joint success!
#70yearsglatt#companyanniversary#innovation#thankyou#glatt
𝗔𝗸𝘁𝘂𝗲𝗹𝗹𝗲 𝗝𝗼𝗯 𝗔𝗻𝗴𝗲𝗯𝗼𝘁𝗲 𝗯𝗲𝗶 𝗚𝗹𝗮𝘁𝘁 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗦𝗲𝗿𝘃𝗶𝗰𝗲𝘀 - 𝗖𝗗𝗠𝗢 𝘂𝗻𝗹𝗶𝗺𝗶𝘁𝗲𝗱
Expert Analytical Development (m/w/d)
Head of Pharmaceutical Development (m/w/d)
Operator in der pharmazeutischen Produktion (m/w/d)
Pharmaziepraktikum, Bachelor- oder Masterarbeit in der pharmazeutischen Entwicklung (m/w/d)
Mehr Informationen hier: https://lnkd.in/e3G8FsNa
A limited number of seats are available for the upcoming Glatt Pharmaceutical Services tech series on June 27, 2024, entitled "Multi-Particulate Drug Delivery Systems", and a live demonstration and tour of the Glatt manufacturing facility. Interested parties are required to register by Wednesday, June 26, 2024.
𝗠𝘂𝗹𝘁𝗶-𝗣𝗮𝗿𝘁𝗶𝗰𝘂𝗹𝗮𝘁𝗲 𝗗𝗿𝘂𝗴 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗦𝘆𝘀𝘁𝗲𝗺𝘀
Glatt Technical Series III on June 27, 2024 ini Ramsey, NJ will focus on the versatility of Multi-Particulate Drug Delivery Systems in manufacturing solid oral dosage forms. These systems include microcapsules, beads, pellets, and nanoparticles.
More information and registration: https://lnkd.in/eeNzUDVJ#pharmaceuticals#multiparticulates#drugdeliveryBASF Pharma SolutionsGlatt Group
𝗣𝗲𝗹𝗹𝗲𝘁𝘀 & 𝗪𝘂𝗿𝘀𝘁𝗲𝗿 𝘁𝗵𝗲 𝗽𝗲𝗿𝗳𝗲𝗰𝘁 𝗰𝗼𝗺𝗯𝗼 💊
Quite some people shy away from pellets and the Wurster process for drug layering and coating. We at Glatt Pharmaceutical Services - CDMO Unlimited just love it - why? Because it is an versatile, efficient, scalable and high quality process when it comes to pellets and especially when it comes to apply functional coatings. Learn more in the video by Glatt Group. More are available in our youtube channel too ;-).
Here are some key factors about the Wurster Process you might not know yet:
Quality
One of the most significant benefits of the Wurster process is its ability to achieve a uniform and consistent drug layering but also coating application. The unique design of the system, where pellets are suspended in an upward airflow, ensures that the drug and coating solution is evenly distributed across each particle's surface. This uniformity is critical for developing uniform drug loading and applying functional coatings for a tailored and consistent drug release profile. This precision allows for improved therapeutic outcomes and better patient compliance, as medications can be tailored to release at specific times or in particular areas of the body.
Scalability
Scalability is another strength of the Wurster process. It is adaptable to various production scales, from small laboratory batches to large commercial manufacturing runs, without compromising the quality of the drug layering and coating processes. This flexibility is invaluable for pharmaceutical companies as they transition from development to full-scale production.
Versatility
The versatility of the Wurster process extends to the range of coating materials it can handle. Polymers, sugars, waxes, and other substances can be used, allowing for customization of the coating's properties such as solubility, permeability, and mechanical strength. This adaptability helps in meeting diverse formulation requirements. The process can run with suspensions and solutions based on aqueous or organic solvents.
Efficiency
Efficiency is also a hallmark of the Wurster process. The controlled environment within the fluid bed system minimizes material loss, ensuring that most of the coating solution is applied to the pellets rather than being wasted. This high efficiency translates to cost savings and reduced resource consumption.
#pellets#coating#wurster#fluidbed
