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5 votes
0 answers
69 views

Why are S-thiocarbamates less toxic than carbamates?

According to Haley and Rhodes, neostigmine bromide (alternatively known as Prostigmine) has an LD50 in mice of around 0.165 mg/kg by IV injection. Pubchem claims that this is also the LD50 for ...
user73910's user avatar
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4 votes
2 answers
132 views

What is the mechanism of AChE inhibition by Onchidal?

A naturally-occuring neurotoxin, called Onchidal, produced by a species of sea slug acts as an irreversible inhibitor of acetylcholinesterase. The structure of Onchidal is presented below: How and ...
user73910's user avatar
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2 votes
0 answers
50 views

Why are carbamates capable of inhibiting acetylcholinesterase?

Certain carbamate compounds, such as the insecticide carbaryl or the Edgewood carbamates such as EA-3990, can inhibit the enzyme acetylcholinesterase. Unlike organophosphorus compounds, however, they ...
user73910's user avatar
  • 1,264
-1 votes
2 answers
101 views

Does water in big cities get heated (boiled) for treatment?

I live in Bangkok and read how water comes to customers here: I understand from the chart that water go through Thon Buri treatment plant (west Bangkok) and Mahasawat treatment plant (east Bangkok) ...
user avatar
23 votes
2 answers
4k views

Why is the cyanide ion toxic?

As the title implies, what is the molecular basis of cyanide toxicity? I did some searching around at the CDC and it only states that it prevents cells from using oxygen. I also read how it could take ...
Aubrey Champagne's user avatar
3 votes
1 answer
132 views

Why does no antitoxin for botulinum type H exist yet?

Antitoxins against the botulinum toxins type A–G produced by Clostridium botulinum are known. Why does none exist against the type H botulinum toxin yet?
Josef's user avatar
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