All Questions
6
questions
2
votes
2
answers
242
views
Loss of entropy and solvation energy in proteins
I am reading a chapter on protein stability. One section outlines the role of salt bridges or ion pairs in the stability of a protein. The excerpt goes as follows (italization added for emphasis):
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- 265
6
votes
1
answer
206
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Biomolecular energy functions and entropy
From what I've been reading, it seems that entropy (rather than enthalpy) is the biggest driver of protein folding (especially the burying of hydrophobic residues). However, popular energy functions ...
- 163
0
votes
1
answer
2k
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Is protein folding thermodynamically favourable? If yes.. why? [duplicate]
The second law of thermodynamics dictates that the sum of entropy of the universe is always increasing. Is the process of protein folding a spontaneous process which is increasing the entropy? Is this ...
- 121
2
votes
1
answer
50
views
What aspects of a macromolecule/protein do the various contributions to its entropy relate to?
I've come across a few different contributions to entropy in macromolecules such as proteins: configurational, conformational and vibrational. The problem is that I can't seem to find a consistent ...
- 21
5
votes
3
answers
2k
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Why are protein hydrophobic cores denatured by heat when entropic forces should be favoured at high temperature
The hydrophobic interaction is thought to be driven by an entropic force. If it is, shouldn't hydrophobic interactions be stronger at higher temperatures, where states of higher entropy are favoured? ...
- 235
1
vote
0
answers
208
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Energy required to break salt bridges in peptides and proteins
Is there a way to calculate the energy required to break a salt bridge in a peptide or on the exposed surface of a protein in aqueous solution? Is there any useful literature on this topic? I'm ...
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