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I understand the basics that chromatography is a fairly slow and expensive process compared to direct synthesis. When a synthesis route is not feasible, the economics become favorable. Not being in the chemical industry, I do not know the specifics of these economics or how common industrial scale chromatography is.

Three applications I know of are sucrose separation from beet molasses, insulin from genetically modified E.coli, and B-Carotene from algae. There are surely many others especially in the pharmaceutical industry, but I have not been able to find a list of specific chemicals.

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  • $\begingroup$ Within pharma the scale-up chemists put a lot of time in to minimising chromatographic separations for drug substances. $\endgroup$
    – Waylander
    Commented Nov 26, 2023 at 22:39
  • $\begingroup$ Most organic chemicals are purified and separated by column chromatography / TLC. $\endgroup$
    – Harikrishnan M
    Commented Nov 27, 2023 at 3:45
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    $\begingroup$ Questions that request lists are frowned upon. You could reformat the question so that it addresses an underlying concept, for instance, "when is chromatography regarded as a viable industrial purification strategy?" And adding some details regarding your own findings. $\endgroup$
    – Buck Thorn ♦
    Commented Nov 27, 2023 at 7:05
  • $\begingroup$ @BuckThorn, Thanks for the feedback! $\endgroup$
    – ericnutsch
    Commented Nov 27, 2023 at 12:08

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