Questions tagged [medicinal-chemistry]
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In drug discovery, what is an undruggable target? [closed]
The term "undruggable" is often use in drug discovery. As far as I understand it, it means "for which no inhibitor has been found so far".
It's a fuzzy, non-satisfying, definition.
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PEGylation safety and hybridomas
PEGylation is the covalent attachment of PEG (PolyEthylene Glycol) to molecules (e.g. proteins). It states in wikipedia ("PEGylation"):
The covalent attachment of PEG to a drug or ...
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How to reduce PPi concentration in blood samples by PPase
I have some samples of whole blood that are a little bit expensive and I want to significantly reduce the concentration of PPi in the samples by causing a reaction. I don't have any experience in ...
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Is it advised to calculate QED parameters for salts?
QED (quantitative estimation of drug-likeness) is a score which helps you to predict if a small molecule is desirable as an orally absorbed drug, described in the Quantifying the chemical beauty of ...
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Identifying substance in body fluid (serum, urine)
I have a large number of serum and 24 hour urine samples from a collection of individuals on many consecutive days. Some of the samples contain a 'large' amount of a substance that has a brown color. ...
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Are drugs made bitter artificially to prevent being mistaken for candy?
All drugs I remember tasting (with the notable exception of Aspirin) have bitter taste. Is the taste due to the active substance, or is a bittering agent added to them, perhaps to prevent overdose?
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Why is half dose of Oxford's vaccine of covid more effective than full dose?
I recently read in a newspaper that the half dose of the Oxford's vaccine is 90% effective while the full dose is only 62% effective.
Why is this the case ?
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Inability of vultures to digest diclofenac
The population of Indian vultures has been rapidly declining since 2003. This is attributed to the diclofenac present in the carcasses which the vultures eat. Vultures seem to digest all sorts of food ...
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Are omeprazole and other members estrogenic and/or antiandrenergic?
As of 2020, omeprazole is a widely used OTC medicine for various types of acute heartburn and some other gastrointestinal disorders.
Almost every time I read about it I read that one of the possible ...
user22497
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Does Cholestyramine (CSM) raise Tyramine levels?
This is a layman's question.
Will ingesting Cholestyramine (CSM, the resin, in powdered form to be specific) raise tyramine levels?
I am asking because Cholestyramine clearly has "tyramine" in its ...
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Sulforaphane vs. Hyperthermic conditioning (sauna use) which would induce a greater heat shock response in the human body?
I’m curious to know which would induce a greater upregulation of heat shock proteins, consuming sulforaphane or putting the body through heat stress such as using the sauna.
Sulforaphane reference- ...
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How does cancerous tissue break down radioisotopes faster than normal tissues?
Apparently, many medical practitioners use radioisotopes to detect cancer in patients. From my textbook (McGraw Bio 12, pg. 10);
Using a method called radioisotope tracing doctors can inject
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Which kind of drugs get absorbed through epidermis?
Some drugs such as nicotine can be administered through skin. I thought the layers of skin are designed to prevent in-flow of any chemical/germs. Not all drugs get absorbed in this fashion. So do ...
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How would a medication cause a one to maintain a different weight?
This isn’t really a medical question, I’m just really curious about this.
I was maintaining weight A and then started taking a medication that brought me to weight B. While on the medication, I ...
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Why is plasma glucose concentration not double that of whole blood?
It is known that the concentration of plasma glucose is 12% higher than that of whole blood. But since 45-50% of whole blood is red blood cells, shouldn't the plasma glucose be almost double — since ...
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