TLDR; Essentially the same answer as Argenti Apparatus, but with more background explanations.
Which among the two is a more performance oriented geometry and which one is more comfortable?
It depends what you mean by "comfortable", if you are referring to fit then
geometry that works well for one body proportions may not work well for another.
I would be careful at interpreting stack:reach ratios as there isn't a single golden ratio, its really person specific. For example, individuals with long legs will want a frame with a taller stack and shorter reach (long legs implies a shorter torso and therefore shorter reach). People with flexibility issues will also want a taller stack. People with shorter legs (and long torso) will want a less stack and more reach to get ideal weight distribution and fit.
I would also be careful about comparing reach numbers between hybrid and endurance road bikes. Road bikes use drop handle bars necessitates a shorter reach compared to a flatbar hybrid (what you are looking at) which will have a longer reach for the same final body position.
Finally, because the head tube is angled reach changes with stack, therefore when comparing two bikes with the same reach numbers, the bike with the higher stack would have a longer effective top tube. That is, to get the same final body position on both frames you would need a shorter stem on the bike with the higher stack numbers. Note differences in effective top tube length impact weight distribution which impacts handling, it also impacts stem length which also affects steering response (see below).
Which among the two is a more performance oriented geometry and which one is more comfortable?
Wheelbase is one indicator, but it is not the indicator, as indicated above there are many factors in balance that predict handling. The Cannondales have longer top tubes (and a shorter stem), more front wheel offset, which contributes to the longer wheelbase numbers you are seeing. Interestingly both the Merida and Cannondale have the same chainstay lengths, which is much longer than road bike or even an endurance road bike chainstays. Both also have similar similar bottom bracket drop, as such the only real difference is in the front end geometry, Merida has a steeper head tube and shorter front end, while the Cannondale a shallower head angle, but more fork offset.
Longer front centers tend to handle rougher conditions a bit better, so I would hazard a guess that the Cannondate would be better here. There will also be less toe overlap with the front wheel which can mean easier low speed handling and better accommodation of fenders (Who hates hitting a fender when turning? I do!), The shorter sharper approach of the Merida would likely be better suited to smoother roads. That said the Merida will also have a longer stem which can also calm down handling, as longer stems tend to subtle the steering response, which then can be used offset or to tune other geometry decisions (like fork offset and head tube angle).
Image Source: How does stem length affect a bike’s steering and handling?
What should you do?
In the end both will probably handle similarly. Also neither have the chainstays or headtube angles of a road bike so they will be a bit more toned down compared to a dedicated road bike.
In practice there probably won't be much practical day-to-day differences between the bikes. Ultimately, I would go with what fits best as my primary criteria, as this will likely be the biggest predictor of whether or not you will like the bike. After that I would other things like slight geometry differences or components, even then these are only minor considerations.
Over the years I found it is really hard to get a feel for how a bike will be by comparing geometry numbers. There are so many different inputs that are balanced together to produce the final feel of a bicycle (even frame tubing selection, a basic unknown, can have a huge impact). Even then, I find it often takes extended time riding (e.g., months) on a bicycle before I really get understand its characteristics. My best advice follows others: Go out and ride them.
