Next time I would be more careful about the people you want to lend your Mac to.. ;)
However:
I would simply check the entire filesystem with an anti virus/spyware/malware of your choice, and I would check regularly on Task Manager if there are processes you find strange or suspicious (better if you remember what was installed on your Mac prior to lending it). In this way you will be almost completely certain that any threat that entered your pc will be gone. Please notice that swapping your hd with a new one would work only if you want to install MacOS from scratch. Copying files from an hd to another would copy any threat as well.
Unless your "friend" is a professional engineer, a detective or something similar, I don't think he/she can put any kind of recording device in your computer without making it noticeable at all. I think a deep check of your Mac appearance can spot most of the potential issues.
if you still want to open your Mac, you can use iFixit (for example, since you said you MacBook was the last before Unibody ones, you can fint the related page here) guides, but be careful since there are cables and connectors that sometimes are very weak and likely to be damaged if you are not an expert.
Since you say you lent it, I presume you know the person that had your Mac in the previous days. Only you can judge if they are enough experienced to put some kind of threats (either software or hardware) in your computer.