This is not about EPS 8 pin look carefully before flagging for that.
Let's look at a 8 pin PCI Express cable plug. One row has three notched connectors and one square. The problematic pin is on the other row, furthest from this square. It's notched usually. The diagram below calls this pin 8 -- I am not sure who made this diagram but it's quoted very often, including this site. I also attached a noname plug (I marked the pin with a blue stripe) and a Corsair plug showing this is notched. However, the PCI Express CEM 3.0 clearly prescribes a squared pin here, a screenshot is also attached (it's not a change in the standard, the earlier PCI Express 225 W/300 W High Power Card Electromechanical Specification was the same). It calls this "position 8". Receptacles as found on video cards do have a squared hole here as the standard prescribes.
As this comment notes, these sort of cable plugs allow a PCIe pinout plug to be inserted the EPS 12V socket which never works and can be catastrophic. That's clearly not what the standard maker wanted. Also, this comment from four years ago treats this pin to be notched self evident. Yet another answer shows this plug notched on an FSP PSU and again notes this is catastrophic for EPS 12V mismatch. (Edit: curiously they note Corsair doesn't notch it -- and looking for this indeed their basic Type 3 and Type 4 cables don't but the premium version does as attached.)
It's not about 2x3 compatibility: this is the two extra pins so in a normal configuration it won't participate when plugging the plug into a 2x3 receptacle. Even if you tried to plug it wrong, it's pin 7 which stops you from that.
So this pin being notched a) is a deviation from the standard b) doesn't matter in PCIe situations c) makes the EPS-PCIe situation much worse. Then why does this pin gets notched commonly?
Commonly, but not always as already noted above for Corsair. I also attached a plug photo from the Seasonic: Power supply cables and their uses page and it does use the correct square as well.