I've had this happen on three different customer machines over the last few months, and for the life of me I can't figure out a lasting solution.
In all cases, it appeared that the problem occurred after a Windows update. I'm not sure which update in particular. I see a BOOTSECT.bak on the System Reserved Partition with a timestamp that coincides with what the customer told me about the updates. So I'm assuming some update is playing with the boot sector and clobbering everything.
Symptoms:
Computer comes in with BSOD (missing BCD)
I boot to WinRE and check DISKPART:
System reserved partition is fine, but the OS partition is RAW
I perform chkdsk and it says "The first NTFS boot sector is unreadable or corrupt", then proceeds to repair errors in the MFT. After chkdsk is complete, I can see the partition, copy files, etc.
After a reboot, the problem returns, like none of my repairs stuck - I've tried rebuilding the boot sector using bootsect /nt60, and it is successful, but bootrec /fixboot always returns "Access is denied".
I've tried every permutation of search terms I can think of and can't find a solution or even a case of the exact same problem.
All three of these computers are older hardware which originally came with Windows 7 and were upgraded (or clean installed). Two were HP machines, and the current one is a Dell Optiplex 380.
Has anyone encountered this? If I can provide any more information that might be helpful, please let me know!