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I've got Toshiba DT01ACA050 500GB HDD. It is specified in HDD as 5v 420mA,12v 420mA.Does this mean i can operate HDD with help of USB to SATA cable??

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  • Most all usb to sata adapters come with a psu for the hard drive as mentioned by Big Chris.
    – Moab
    Commented Feb 25, 2016 at 16:58

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No. USB can only provide 5V. Any 3.5" HDD requires both 5V and 12V power rails - therefore a USB to SATA will not power the disk. You will require an external power source for the disk.

See the mains adapter in this image:

enter image description here

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