I have this problem with my new Dell Inspirion 3593 with 8 GB RAM and very fast 512 GB SSD.
Disk usage jumps to 100% and lasts for tens of minutes! During this time, everything is so sluggish, unbearable. Even if I try to reset the computer, it needs more than ten minutes ("Restarting..."). You can make a tea meanwhile, waiting for the response.
There are different suggestions on web . I tried this article:
10 Best Ways to Fix a 100% Disk Usage on Windows 10.
None of them did solve the problem completely, although 4th ("Disable Windows Search") helped much.
But the 8th solution (Reset Virtual Memory) gave me the clue.
Namely, Windows 10 has a very strange configuration of Page File. It is configured to manage it automatically, but it has a very low value of 1152 MB!!!
I disabled it and the problem was gone!
However, I got another problem: if I start Firefox and Chrome simultaneously, Chrome reports there is no free memory. Task Manager shows that these two programs occupied almost all free RAM. So, it can not work without Page File.
For years Microsoft have been teaching us that Page File size should be between 1.5 and 4 times larger than physical RAM. And what is this on Windows 10? Some crumbs? I don't understand this.
So, the final answer is to set custom Page File size as in this article:
How To Manage Virtual Memory (Pagefile) In Windows 10
Note that in this example, there is a 2 GB of RAM and the Page File is adjusted between 3072 MB and 8192 MB.
Conclusion: now I have three users logged in simultaneously, RAM used to the top of it, large Page File, but disk C is 0% used and OS is lightning! Research continues...