Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul-Aug;29(4):308-15.
doi: 10.1016/j.gaceta.2014.12.003. Epub 2015 Jan 19.

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Gemma Castaño-Vinyals  1 , Nuria Aragonés  2 , Beatriz Pérez-Gómez  2 , Vicente Martín  3 , Javier Llorca  4 , Victor Moreno  5 , Jone M Altzibar  6 , Eva Ardanaz  7 , Sílvia de Sanjosé  8 , José Juan Jiménez-Moleón  9 , Adonina Tardón  10 , Juan Alguacil  11 , Rosana Peiró  12 , Rafael Marcos-Gragera  13 , Carmen Navarro  14 , Marina Pollán  2 , Manolis Kogevinas  15 ; MCC-Spain Study Group
Collaborators, Affiliations
Free article

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Gemma Castaño-Vinyals et al. Gac Sanit. 2015 Jul-Aug.
Free article

Erratum in

Abstract

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.

Methods: Between 2008-2013, 10,106 subjects aged 20-85 were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,112 cases with a new diagnosis of prostate cancer, 1,738 of breast cancer, 2,140 of colorectal cancer, 459 of gastro-oesophageal cancer, 559 cases with chronic lymphocytic leukaemia and 4,098 population controls frequency matched to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects.

Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.

Keywords: Breast cancer; Case-control; Caso-control; Chronic lymphocytic leukemia; Colorectal cancer; Cáncer colorrectal; Cáncer de mama; Cáncer de próstata; Cáncer gástrico; Epidemiology; Epidemiología; Gastric cancer; Leucemia linfática crónica; Prostate cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Comparing Data from Three Satellites on Artificial Light at Night (ALAN): Focusing on Blue Light's Influence on Colorectal Cancer in a Case-Control Study in Spain.
    Harding BN, Palomar-Cros A, Valentín A, Espinosa A, Sánchez de Miguel A, Castaño-Vinyals G, Pollán M, Perez B, Moreno V, Kogevinas M. Harding BN, et al. Environ Health Perspect. 2024 May;132(5):57702. doi: 10.1289/EHP14414. Epub 2024 May 17. Environ Health Perspect. 2024. PMID: 38758117 Free PMC article. No abstract available.
  • Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.
    Sassano M, Seyyedsalehi MS, Collatuzzo G, Pelucchi C, Bonzi R, Ferraroni M, Palli D, Yu GP, Zhang ZF, López-Carrillo L, Lunet N, Morais S, Zaridze D, Maximovich D, Martín V, Castano-Vinyals G, Vioque J, González-Palacios S, Ward MH, Malekzadeh R, Pakseresht M, Hernández-Ramirez RU, López-Cervantes M, Negri E, Turati F, Rabkin CS, Tsugane S, Hidaka A, Lagiou A, Lagiou P, Camargo MC, Curado MP, Boccia S, La Vecchia C, Boffetta P. Sassano M, et al. Gastric Cancer. 2024 May;27(3):461-472. doi: 10.1007/s10120-024-01476-8. Epub 2024 Mar 4. Gastric Cancer. 2024. PMID: 38436761 Free PMC article.
  • Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project.
    Song M, Jayasekara H, Pelucchi C, Rabkin CS, Johnson KC, Hu J, Palli D, Ferraroni M, Liao LM, Bonzi R, Zaridze D, Maximovitch D, Aragonés N, Martin V, Castaño-Vinyals G, Guevara M, Tsugane S, Hamada GS, Hidaka A, Negri E, Ward MH, Sinha R, Lagiou A, Lagiou P, Boffetta P, Curado MP, Lunet N, Vioque J, Zhang ZF, La Vecchia C, Camargo MC. Song M, et al. Cancer Causes Control. 2024 Apr;35(4):727-737. doi: 10.1007/s10552-023-01829-1. Epub 2023 Dec 20. Cancer Causes Control. 2024. PMID: 38123742
  • Smoking history and breast cancer risk by pathological subtype: MCC-Spain study.
    Peñalver-Argüeso B, García-Esquinas E, Castelló A, de Larrea-Baz NF, Castaño-Vinyals G, Amiano P, Fernández-Villa T, Guevara M, Fernández-Tardón G, Alguacil J, Obón-Santacana M, Gómez-Acebo I, Pinto-Carbó M, Marcos-Gragera R, Aragonés N, Aizpurua A, Martín-Sánchez V, Ardanaz E, Dierssen-Sotos T, Jiménez-Moleón JJ, Kogevinas M, Pollán M, Pérez-Gómez B. Peñalver-Argüeso B, et al. Tob Induc Dis. 2023 Nov 30;21:157. doi: 10.18332/tid/174132. eCollection 2023. Tob Induc Dis. 2023. PMID: 38034128 Free PMC article.
  • Circulating miRNAs signature on breast cancer: the MCC-Spain project.
    Gómez-Acebo I, Llorca J, Alonso-Molero J, Díaz-Martínez M, Pérez-Gómez B, Amiano P, Belmonte T, Molina AJ, Burgui R, Castaño-Vinyals G, Moreno V, Molina-Barceló A, Marcos-Gragera R, Kogevinas M, Pollán M, Dierssen-Sotos T. Gómez-Acebo I, et al. Eur J Med Res. 2023 Nov 4;28(1):480. doi: 10.1186/s40001-023-01471-2. Eur J Med Res. 2023. PMID: 37925534 Free PMC article.
See all "Cited by" articles

Publication types

MeSH terms