The catalytic asymmetric polyene cyclization of homofarnesol to ambrox is achieved using a highly Brønsted-acidic and confined imidodiphosphorimidate catalyst.

Cryo-electron microscopy structures of the noradrenaline transporter (NET) reveal binding modes of adrenaline, coordination of sodium and chloride ion binding and the binding sites and mechanisms of inhibition by conotoxin, bupropion and ziprasidone.

In Drosophila, dopamine sets motivational state during mating by regulating the integration of competing drives in copulation decision neurons, potentially indicative of a more general role for control over neuronal integration time in the regulation of behavioural decisions.

Serotonin has a role in ependymoma tumorigenesis through modifying histones and thereby regulating key transcription factors and activating specific oncogenic transcriptional networks in brain cells.

Cryo-electron microscopy structures of NMDA receptors in open and apo states reveal the molecular mechanism underlying the dual ligand requirement for its channel gating and opening.