Nutrients, Volume 11, Issue 10 (October 2019) – 290 articles
Cover Story (view full-size image):
Gluten-related disorders include celiac disease, wheat allergy and non-celiac wheat sensitivity, which have in common the dietary exposure to gluten and other wheat derivatives as an etiologic factor. Of notice, each present a unique pathophysiology: celiac disease is mainly a T-cell mediated condition; wheat allergy is characterized by a rapid IgE-dependent or -independent immune response and the basis of non-celiac wheat sensitivity is an innate immune response. Impairment in the epithelial barrier function is a common feature in gluten-related disorders. However, whether it is a primary condition within the pathophysiology of these diseases is still a matter of debate. The paper gives an overview of the reported barrier defects in gluten-related disorders and supports the hypothesis of a primary involvement of the epithelial barrier function in the development of those conditions. View this paper.
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