Int. J. Mol. Sci., Volume 19, Issue 4 (April 2018) – 343 articles
Cover Story (view full-size image):
GTPases control cellular processes by toggling between an active and an inactive state. The most prominent family members—H-Ras, N-Ras, and K-Ras isoforms—are frequently mutated in cancer. As plasticisers, bisphenols are widespread in modern life. BPA, BPAF, BPB, BPE, BPF, and BPNH2 interact with GDP-bound Ras through binding to a common site. This study reveals a new bisphenol-induced, allosterically activated GDP-bound Ras conformation that defines these plasticisers as Ras allosteric agonists. View the paper here.
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