Heart failure affects an estimated 40 to 60 million individuals globally. Find out how Sartorius and the biotech company Repairon are #InThisTogether for a cure 🤝💛 Shortly after birth, our heart muscle cells lose their ability to divide. This means that damage such as a heart attack leads to an irreversible loss of these cells. As a result, the heart's ability to pump effectively decreases, which can lead to heart failure. For over two decades, the team at Repairon has been researching to develop the so-called heart patch. This new heart tissue is artificially grown from stem cells in the lab and then sewn onto special membranes compatible with the human body. ❤️🩹 ➡️ Discover how Sartorius supports Repairon in the production of stem cells for heart patches on the Sartorius Blog: https://ow.ly/gPXZ50Svinq #SimplifyingProgress #PartOfTheSolution #HeartFailure #HeartPatch #Production
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Today's effort at patient education: "Are Stem Cells Illegal?" MSK and Spine autologous cellular therapy injections (like #BMAC and #mFAT) may be considered "exempt" from FDA regulation --- when performed under the proper circumstances, and when specific criteria are met. On the other hand, there are currently ZERO (Zero.Point.Zero) FDA -approved "Stem Cells in a Vial" products for use in the treatment of MSK and Spinal Conditions in the USA. So if you got an invitation for the "Informational Seminar on Stem Cells" at your local steakhouse in the mail, and you show up and they start talking about Exosomes, Wharton's jelly, umbilical cord blood, and amniotic fluid, you might want to skip dessert and skeedaddle. I can't believe that these companies are still getting away with advertising, promoting, and distributing these products in 2024! Hopefully this video helps to clarify! https://lnkd.in/e4EBcuKV
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Exciting research uncovers the therapeutic potential of extracellular vesicles (EVs) in regenerative cell therapies! #EVs #CellTherapy #ExtracellularVesicles #Flowcytometry #Cellsorting #Imagingflowcytometry #Imagestream Exeter Centre for Cytomics
📚 Publication Alert: Nanovials used to optimize cell therapies! In a recent Nature Communications publication, researchers at UCLA used Nanovials to identify and isolate high EV secreting stem cells and used them as a therapeutic in mice, demonstrating improved tissue regeneration post-cardiac injury. Key Takeaways from the publication: 📌 EVs play an important role in cell-to-cell communication 💬, including tissue regeneration 📌 Traditional methods, which study EV-secreting cells in bulk, often mask this heterogeneity and typically destroy the cells, making it difficult to optimize EV therapeutics 📌 Nanovials were used to analyze and sort single cells based on EV secretion levels—cells are kept alive during this process 📌 Imaging cytometry 📸 using the Cytek Biosciences Amnis Imagestream helps distinguish different Nanovial populations 📌 Mice treated with high EV secreting populations isolated using Nanovials show increased tissue recovery after myocardial injury 🐭 🚀 Nanovials can facilitate the optimization of other EV therapies! Read the press release here: https://lnkd.in/gvf8U7ZW Read the publication here: https://lnkd.in/gGt2FTNP #CellTherapy #ExtracellularVesicles #Nanovials #Therapeutics
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📚 Publication Alert: Nanovials used to optimize cell therapies! In a recent Nature Communications publication, researchers at UCLA used Nanovials to identify and isolate high EV secreting stem cells and used them as a therapeutic in mice, demonstrating improved tissue regeneration post-cardiac injury. Key Takeaways from the publication: 📌 EVs play an important role in cell-to-cell communication 💬, including tissue regeneration 📌 Traditional methods, which study EV-secreting cells in bulk, often mask this heterogeneity and typically destroy the cells, making it difficult to optimize EV therapeutics 📌 Nanovials were used to analyze and sort single cells based on EV secretion levels—cells are kept alive during this process 📌 Imaging cytometry 📸 using the Cytek Biosciences Amnis Imagestream helps distinguish different Nanovial populations 📌 Mice treated with high EV secreting populations isolated using Nanovials show increased tissue recovery after myocardial injury 🐭 🚀 Nanovials can facilitate the optimization of other EV therapies! Read the press release here: https://lnkd.in/gvf8U7ZW Read the publication here: https://lnkd.in/gGt2FTNP #CellTherapy #ExtracellularVesicles #Nanovials #Therapeutics
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PhD Student in Stem Cells and Biomaterials | InovContacto C26 @ Inflammatix | Biological Engineer @ IST/KU Leuven
Last month our newest article from COMPASS Research Group got published in #AdvancedHealthcareMaterials! This is a very interesting article that combines the use of stem cells and biomaterials to explore the immunoregulatory potential of MSCs and MSCs-derived products. It is entitled "Encapsulated Mesenchymal Stromal Cells as Cyclic Providers of Immunomodulatory Secretomes: A Living on-Demand Delivery System" and was developed with the contributions of Ana Rita Sousa, Diana Gonçalves, Ana Santos Coquillat, Mariana B. Oliveira, and João F. Mano. Check it out: https://lnkd.in/d-vBSkbh #Secretome #StemCells #Biomaterials #Immunomodulation #Stimuli #MSCPrimming
Encapsulated Mesenchymal Stromal Cells as Cyclic Providers of Immunomodulatory Secretomes: A Living on‐Demand Delivery System
onlinelibrary.wiley.com
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Facing the looming challenge of treating nearly 300 million individuals with age-related macular degeneration (AMD) by 2040, the medical community seeks innovative solutions. Recent studies highlight the potential of microcarriers in revolutionizing cell-based treatment of AMD via the production of retinal pigmented epithelial cells derived from human pluripotent stem cells (hPSC-RPE). Yet, common market options face efficiency and integrity issues. Smart MCs, pioneering a new era with customisable, xeno-free microcarriers tailored for specific applications. Dive deeper into this groundbreaking solution and discover how Smart MCs is reshaping the future of cellular therapies. Read More: https://lnkd.in/gNaiPaQr #age_related_macular_degeneration #AMD #hPSC #pluripotent #pluripotent_stem_cells
Addressing the Global Age-Related Macular Degeneration Crisis: Advanced Microcarrier Technology Offers Hope
https://smartmcs.com.au
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What are stem cells? Stem cells are particular types of cells that can develop into many different types of cells in the body. They have specialized functions such as self-renewal through cell division and differentiation into specific types of specialized cells, such as red blood cells, insulin-producing cells, neurons, or other blood cells. Did you know that GLUTATHIONE is needed to increase stem cell potency and differentiation?🙌❤️ GlutaMyst is a convenient, effective, efficient, delicious, and affordable INNOVATIVE DELIVERY TECHNOLOGY that gets 100% Pharmaceutical-Pure Medical-Grade Glutathione with a proprietary blend of 60 cellular nutrients into your body within 4 seconds and absorbs up to 99%.
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Producing stem cells-derived EVs at scale: in their latest work, Christian M. Capitini & Peiman Hematti at University of Wisconsin-Madison and collaborators assessed the viability of producing MSC-derived extracellular vesicles on a large scale using a bioreactor and to evaluate essential quality control parameters such as identity, sterility, and potency in educating monocytes and enhancing survival in a lethal hematopoietic acute radiation syndrome murine model https://lnkd.in/e4mKTqgs Large-scale cultivation of lipopolysaccharide-primed MSCs in a hollow fiber bioreactor demonstrated efficacy in treating H-ARS, showcasing the potential of a scaled-up manufacturing process for generating an appealing off-the-shelf, cell-free therapy. An article also authored by John Kink, Michael Bellio, Matthew Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene Ong and Aisha Khan #extracellularvesicles #exosomes #bioreactors #gmpcompliance #stemcells #Vesiculab
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🔬 Accelerate your #celltherapy workflows and deliver new treatments with MatriClone! Discover a new comparative data set featuring MatriClone among 4 iPSC matrices, evaluated for their ability to support iPSC cell lines. The study explores both the conventional pre-coating protocol and the innovative in-solution method, providing valuable insights into the most efficient techniques. MatriClone stands out as a robust matrix, purposefully designed to foster the health and pluripotency of induced pluripotent stem cells (iPSCs). Unlike traditional iPSC matrices, MatriClone offers optical compatibility for whole well imaging, a crucial factor for regulatory approval. Notably, it's also soluble, eliminating the need for time-consuming pre-coating of plates. Unlock the full potential of iPSCs in your research and development. Read more here: https://lnkd.in/ehhG65-h... #celllinedevelopment #stemcells #innovation #biotech
Insti-Blog - A Comparative Data Set Showcasing MatriClone Matrices for iPSCs | Advanced instruments
https://www.aicompanies.com
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Field Application Specialist @Sartorius || Ex-Dr Reddy's Laboratories LTD || Ex-Biocon Bristol Myers Squibb R&D Centre || Ex-CCMB || IIT Delhi || NIBM || Alumni of Sri Ramachandra University|| Alumni of Jain University
The Cellcelector platform plays a pivotal role in this endeavor by offering precise and efficient cell isolation capabilities. Researchers can use Cellcelector to selectively isolate specific cell populations derived from human pluripotent stem cells, allowing for the creation of complex in vitro disease models that closely mimic the cellular heterogeneity observed in human tissues. By enabling the isolation of disease-relevant cell types with high purity and viability, Cellcelector facilitates the development of more accurate and physiologically relevant disease models, ultimately advancing our ability to study disease mechanisms and identify novel therapeutic targets. Click on the link below to explore further on the technology. #cellcelector #automation #CRISPR #hPSCs
Disease modeling of human pathologies in vitro using human pluripotent stem cells (hPSCs) is increasing in the scientific community. Read about this novel method of hPSC clonal isolation to improve and upscale the generation of edited hPSCs required for downstream applications including disease modeling and drug screening and the role that CellCelector played: https://ow.ly/9zMo50QQPHm #stemcells #CRISPR #automation #cellcelector #lifescienceresearch
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MEMS removing the non-degradable proteins from the networks stops the cell degeneration in situ Between degeneration using chemicals and complicated regeneration, the ill patient cannot work. The transplantation is expensive and invasive, with the risk of infection, and social security is a problem in any country that cannot reimburse it. The company taking part in the studies has known from Axanton Technology GmbH for 10 years that removing the non-degradable proteins with Molecule Establishing Membranes Signaling (MEMS) regenerates the cells in situ and prevents cardiovascular pathology. MEMS is used sublingually at five micrograms per week to prevent cardiovascular pathologies in humans for 14 years. Where is the science and regulatory affairs policy to refuse all financial support since 2005 for MEMS and continue to tolerate the accumulation of the non-degradable proteins in the cell and the patients' degeneration? https://lnkd.in/eUSx5HyA
Latest Review on Human Pluripotent Stem Cell-Derived Cardiomyocytes published on #CellStemCell. Raniga and colleagues discussed the applications of hPSC-CMs in drug discovery and the path to clinical translation, highlighting several key challenges: 1. Raw Materials in Cardiac Differentiation Protocols The raw materials used in cardiac differentiation protocols are often of research grade and not optimized for clinical applications. Even when the focus is non-clinical research, it's important to consider the potential for future translational needs and adhere to relevant regulatory guidelines. I am looking at you, Matrigel. 👀🐭 2. Scaling Up the hPSCs Scaling up remains a significant hurdle in the realm of cell therapy. Traditional 2D differentiation processes fall short in scalability due to the inefficient surface area-to-volume ratio for cell growth. Bioreactor-based manufacturing has emerged as a solution, improving quality and overcoming many of these limitations. 📈 3. Gender-Balanced, Ethnically Diverse hPSC lines Let's address the elephant in the room - lack of diversity in clinical research. The current hPSC repositories in the US and Europe predominantly feature Caucasian lines, with an uneven distribution of male and female hPSC lines (who would have guessed, right?). While diverse donor cell lines are now available, they often come at a premium under custom services, making them an expensive option for researchers. 💸 Read the author's perspective in detail: https://lnkd.in/e3-kRPnK #ipsc #cardiomyocytes #celltherapy
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1wThis is truly unique... almost like sci-fi, but real!