Protak Scientific Limited’s Post

As mentioned in our previous post, we introduced Seqens CRDMO services. Additionally, Inabata will be exhibiting "T3P," manufactured by Curia, at the Summer Symposium of JSPC. T3P is a well-known coupling reagent, but qualified sources are limited due to restrictions and its product characteristics. Inabata has been supplying Curia's T3P to the Japanese market for almost 10 years. T3P is not only a very useful coupling reagent for large-scale synthesis but is also applicable to various reactions such as oxidation and reduction. The peptide market and peptide-mimetic applications are expanding, and the demand for Curia's T3P is increasing steadily, even in Japan. Inabata continuously pursues the potential business of T3P in the Japanese market.

Download this application demonstrating the analysis of the lipid components of patisaran (trade name Onpattro). Optimal separation of the four LNP components with excellent peak shapes, precision, and sensitivity was achieved https://lnkd.in/gSd3EQAr

NEULAND LABORATORIES: Q2 CONS NET PROFIT 892M RUPEES VS 385M (YOY) NEULAND LABORATORIES: Q2 EBITDA RUPEES 1.37B VS 693M (YOY) || Q2 EBITDA MARGIN 32.91% VS 23.59% (YOY) BIG BEAT YOY

A simple explanation of the potential value and efficiency gains of an Interchangeability designation for a biosimilar.

Driven by a strong geo-political de-risking of overly dependent supply chain arrangements, a drastic rethinking about searching for and developing alternative options is underway in the pharma industry. This is evidenced by several leading companies defining new policies and the separation of activities from select countries.   Primopus has been working diligently to repurpose the pharma Intermediate and API facility it acquired in Switzerland and lays heavy emphasis on sustainable solutions. Our utilities will be net zero carbon from 2028 onwards.  The backward integration to our parent company Deccan Fine Chemicals in India brings massive scale and a huge resource of scientists who have experience in safely scaling-up of complex molecules.   With the launch of our Amideus brand this year, a lot of focus continues to be put on developing, scaling up and supplying of Phosphoramidites (RSMs) to the Oligonucleotide modality which is rapidly gaining interest in the industry.    As the offering broadens with additional critical RSM’s and custom intermediates we are listening to more customers asking about a 2nd independent supply chain option for their strategic API’s. This trend is accelerating and the importance of our Swiss/Indian cultural blend is pivotal in our hybrid value proposition which ultimately improves the reliable supply of essential and complex medicines to global patients.   Contact us today using the link below to discuss how we can support your supply chain needs. https://lnkd.in/efJyyTbH   #pharmasupplychain #RSMs #primopus #pharma #phosporamidites #oligonucleotides #CDMO #Amideus #supplychain #pharmaindustry

Optically active secondary alcohols are key building blocks for a variety of chiral drugs, and transition-metal-catalyzed asymmetric hydrogenation represents one of the most efficient and direct methods for the preparation of chiral secondary alcohols. We herein report a practical and efficient asymmetric hydrogenation catalyzed by a chiral iridium complex bearing (R)-O-SpiroPAP as the ligand, producing intermediates of crizotinib, ensartinib, lorlatinib, and pibrentasvir in up to 99% yield with up to 99% ee and >20:1 dr. The synthetic potential of the current catalytic system was demonstrated by experiments on the gram and kilogram scales. Practical Access to Key Intermediates of Crizotinib, Lorlatinib, and Pibrentasvir Enabled by Oxa-Spirocyclic Ligands Jingyuan Song, Menglong Zhao, Renwei Xiao, Gen-Qiang Chen*, and Xumu Zhang* Cite this: Org. Process Res. Dev. 2023, 27, 12, 2280–2285 Publication Date:November 9, 2023 https://lnkd.in/gaTT3rev

Excited to share our latest breakthrough: the Palladium-catalyzed arylation of hydantoins, pivotal structural components found in numerous pharmaceuticals. This method offers an efficient pathway to a diverse range of compounds, including derivatives of anticonvulsant medications, phenytoin and mephenytoin, when utilized alongside stepwise deprotection methods. Learn more about our groundbreaking research!

Atenolol belongs to a class of drugs known as beta blockers. Atenolol Used to treat high blood pressure (hypertension) and irregular heartbeats (arrhythmia). Atenolol controls high blood pressure and angina but does not cure them. It may take 1-2 weeks before you feel the full benefit of Atenolol. Atenolol Degradation impurity, Atenolol Process impurity, Atenolol Potential impurity, Atenolol USP Related Compound, Atenolol N-Nitroso impurity, Atenolol nitrosamine impurity etc. are available in Karpschem. Certificate of Analysis (CoA) and Characterization Data: All products are provided with a certificate of analysis (CoA) along with the characterization data like 1H-NMR, MASS, HPLC Purity, MSDS, etc. (whatever relevant and possible). Moreover, additional data like 13C-NMR, 13C-DEPT NMR, GC, GC-MS, IC, Potency, TGA, etc. will be provided on request (extra charges may apply). For inquiries & quote please log on to www.karpschem.in or Email on info@karpschem.in #impurities #standards #cro KARPSCHEM LABORATORIES PRIVATE LIMITED Dr. Amit Sureshrao Nagare

At the upcoming Process Development for Highly Potent Drugs Summit in Philadelphia, PA, June 25 - 27, Dec Group CST Director Andrew Lemaire will give insight on navigating the challenges in integrating off-the-shelf lab scale equipment with containment technology in a high containment HPAPI kilo lab & production development scale plant. In this lecture, he will discuss the various considerations that need to be made when integrating equipment and the potential risks of exposure that come with it. He will explore the completion of a 10 isolator OEB6 development scale plant. The challenges faced during this project will be analyzed, along with the strategies used to overcome them. By presenting this case study, we hope to provide valuable insights into the best practices for equipment integration. Join us for this engaging and informative lecture and learn from real-world examples to gain valuable knowledge that can help you navigate similar challenges in your own projects. 👉 Event website: https://hpapi-summit.com/ #decgroup #hpapisummit #highcontainment #processintegration #processisolation #hpapi