Oregon State University’s Post

A rapid, cost-effective in vitro method for assessing the stability of oligonucleotide duplexes, crucial for the development of oligonucleotide therapeutics targeting orphan diseases and cancer :https://lnkd.in/gp9rsJhk 🔹The method addresses the challenge of oligonucleotide instability, especially RNA, in intracellular and circulation conditions. 🔹The protocol suits various oligonucleotide types (siRNA, miRNA, ASOs) without requiring high-level biosafety clearance. 🔹It aids in selecting ideal modification patterns for in vivo analysis, boosting effective therapeutic development. Work by Shreyas Ganesan Iyer and Andrea Kasinski at Purdue University. Reviewed by Chiara Ambrogio, Wendy Hempstock, and Catherine Hurd. Explore publishing with Bio-protocol at https://lnkd.in/gR3QGYz6. #openaccess #reproducibility #lifesciences #research #biochemistry

Despite the success of delivery technologies such as lipid nanoparticles and trivalent GalNAc conjugation, targeted delivery of oligonucleotides to extra hepatic tissues remains a challenge. WuXi AppTec recently presented a poster showing the utilization of our peptide-based DNA-encoded library screening platform to identify endocytosis receptor-binding peptides. The binding affinity of hit peptides was confirmed through biophysical assays, and target-based delivery efficiency in breast cancer cells was evaluated by flow cytometry. These results highlight the potential of this approach for developing peptide-oligonucleotide conjugates for peptide-based drug delivery. Curious to learn more? Click 👇 to view our poster. Questions? Contact us by clicking here: https://lnkd.in/eG97YXCs #Biotech #Biopharma #DrugDiscovery #DEL #Endocytosis #Peptides #PeptideConjugates https://lnkd.in/gvKx75-J

New Research Paper 📜📜📜📜📜📜 Title:- Design, synthesis and biological activities of Dispiroimidazolidine-Pyrrolizine/pyrrolidine derivatives via 3 component 1,3-Dipolar cyclo -addition reaction. Abstract:- Pyrrolizine/pyrrolidine scaffolds have long been described for their encouraging biological responses such as anti-cancer, anti-microbial, anti-viral, etc. Hydantoin, a versatile pharmacophore, has also been employed for developing a variety of bioactive molecules. Therefore, we anticipated to integrate these two privileged moieties into a single one for enriched biological applications. In this work, we developed an effective synthesis of Dispiroimidazolidine Pyrrolizine/pyrrolidine conjugates via 1, 3-cycloaddition reaction of azomethine ylides generated in situ by the 8-bromotryptanthrin and Acyclic/Cyclic α-amino acid with the Knoevenagel adduct derivatives (derived from the reaction of Hydantoin with substituted benzaldehydes) We further evaluated anti-bacterial, anti-fungal and cytotoxicity activity of all the compounds against MCF-7 human breast cancer cells. Compound 3A-1 & 2, 3 B-1 & 2 and 3 A-9 & B-9 containing 4-flouro and nitro substituent on Phenyl ring and furyl with Bromo atom on Indolo[2,1-b]quinazoline-6,12-dione nucleus showed better activity having IC values 1.82 µg/ml,1.94 µg/ml & 1.88 µg/ml respectively.

On #WorldCancerDay, we are committed to a #GlobalCancerMoonshot, driving progress to decrease the cancer burden worldwide by providing specialized capabilities to support cancer research. In 2022, an international team of scientists, including four researchers from #BioBSE: Leanne Chan, Edward Baidoo, Chris Petzold, and Jay Keasling, developed a yeast platform for #biomanufacturing precursor molecules to produce vinblastine. This anti-cancer drug is plant-derived and could previously only be obtained in trace concentrations in the native plant. https://lnkd.in/gbzVT8Eu U.S. Department of Energy Office of Science Berkeley Lab. #syntheticbiology

New treatments that are effective against resistant mutant AML is of high unmet need. Download this publication to learn how Crown Bioscience collaborated with Hanx Biopharmaceuticals and other cancer researchers for this study, investigating the efficacy of narazaciclib, a novel multi-kinase inhibitor, and how it targets and inhibits key kinases involved in AML models. You can also learn more about which Crown Bioscience AML preclinical models were used. #OncologyResearch #DrugDevelopment #AcuteMyeloidLeukemia

We're thrilled to announce the publication of groundbreaking research on narazaciclib and its anti-AML activity in preclinical models with specific AML mutations of clinical significance. This collaboration between Hanx Biopharmaceuticals, Crown Bioscience, and other cancer researchers has revealed promising results in targeting and inhibiting key kinases involved in AML. Dive deeper into our findings and discover how our collaborative efforts are contributing to treatments for AML. ➡️ https://bit.ly/3UrLjH7 #OncologyResearch #DrugDevelopment #AcuteMyeloidLeukemia

Discovery of YAP1/TAZ pathway inhibitor with potent anti-tumor activity via blockade of Rho-GTPase signaling. The studies described here identifies a small molecule Bay-593 which inhibits geranylgeranyltrasferase-1 (GGTase-1) complex as the direct target of oncogenic protein YAP1/TAZ. Thus, Bay-593 blocks the activation of Rho-GTPases, leading to subsequent inactivation of YAP1/TAZ signaling and inhibition of cancer cell proliferation. Cell Chemical Biology, March 26, 2024.

Pfizer has invested $25 million in CellCentric to fund development of a potential treatment for multiple myeloma and other cancers. CellCentric, a biotech firm based in Cambridge, U.K., is developing an oral inhibitor of p300 and CBP, a pair of proteins implicated in the expression of genes that drive the development of cancer—notably, inhibition of the proteins affecting MYC and IRF4, oncogenes that are important to the progression of hematological cancers. Hitting the proteins also affects the expression of a receptor involved in late-stage prostate cancer. Read: https://lnkd.in/eaiGxssh #sciencesdelavie #biotechnologie #biotechnology #innovation #recherche #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chimie #biology #biologie #biopharma #rna #rnatherapeutics #arn #wewillwin

Molecular Insights into Cancer Drug Resistance| Cancer Drug Resistance| #biotech #cancerbiology #biotechnology #cancer #cancerresearch #biology #drjyotibala #cellbiology #lifescience #molecularbiology #molelixirinformatics #genetics

If you are interested in the potential of NK cells for cancer immunotherapy and on how to engineer them, check our recent review in the journal Biotechnology Advances. #immunotherapy #NK #celltherapy #bioengineering