Mesoporous silica is a type of silica material with an ordered pore structure.The diameters of these pores typically range from 2 to 50 nanometers and can be used for drug loading and release.Modification of paclitaxel on mesoporous silica carriers can achieve high drug loading capacity and improve its stability. Mesoporous silica-loaded paclitaxel modified with PEG/inhibitor can achieve efficient loading and targeted delivery of paclitaxel,while reducing the toxic side effects of the drug.
#Mesoporous#silica#diameters#paclitaxel#capacity#nanometers#PEG#inhibitorhttps://lnkd.in/gAw2Bfc8
Contamination is a critical challenge in the Pharmaceutical & Biotech industries, where purity is non-negotiable. Constant CIP and SIP processes demand robust solutions that can withstand extreme conditions without faltering. That's where the innovation of Tuf-Steel® gaskets comes in—a fusion of PTFE and 316L stainless steel designed for durability and longevity under rigorous SIP and WFI applications. With the ability to endure extreme temperatures and resist creep and cold flow, Tuf-Steel® is redefining reliability. Experiencing is believing! I'm ready to visit and demonstrate how Tuf-Steel® can enhance your processes with its superior performance from -320°F to 550°F. Let's ensure your systems are leak-free and downtime is minimized. Drop me a message to see Tuf-Steel® in action. 😎
#TufSteel#PharmaceuticalManufacturing#BiotechInnovation#REPASSASingapore#RubberFab#Garlock#Gasket#ConsumableProduct
Pay attention to Bioreactors.net novel magnetic coupling mixing drive. This drive is different. Watch the video and you will see that there is no rotating shaft, but the mixers rotate. This principle determines several advantages. For example, it allows easier scale-up, which is a challenge for traditional magnetic drives. We will demonstrate it at ACHEMA 2024.
https://lnkd.in/dwNAbn7W
Tubular Centrifuge | Tubular centrifuge is device used for a wide range of applications, including the separation of liquids, liquid-liquid mixtures, and liquid-solid mixtures.
In this week's 5 minute surfactant capsule we discuss how anionics (more than half by weight of all surfactants) are made today. We also touch on dioxane. Thanks to Ballestra of Italy for most of the information provided. As always, links below the video provide more details and access to 8 downloadable pieces of literature relating to process technology in the fields of surfactants, dtergents and soaps. Thanks for watching.
https://lnkd.in/eSAPTAyE#surfactants
This proposed rule of thumb sounds like it could potentially be as useful as Lipinski’s Rule of 5 itself? Imagine if all medicinal chemists supplied their own data to some kind of public database to really verify whether this approximation for bioavailability holds true for most kinds of small molecules?
I believe everyone these days has sufficient ab initio (or an approximation hereof) calculation power in Chem3D or similar programs to calculate the polar surface area (PSA) used in the below 2D-plot. The database could be supplied with some of the other more classic parameters that everyone has on file anyway, such as number of heteroatoms, logP, logD etc. to generate a multidimensional database instead.
Maybe general solubility for novel molecules could also be predicted by such a polar surface area quantum mechanical calculation and checked against the database once the actual solubility is measured?
Obviously, the actual chemical structures, their intended biological targets and any other confidential information would remain absolute secrets.
Only anonymized physical chemical parameters would need to be revealed before another entry can be plotted in a graph similar to the one below - but “just” with thousands and thousands of entries if all medicinal chemists and other drug developers, industrial and academic alike, “buy into” such a type of information sharing.
(He he he - maybe supplied with some kind of AI to keep track of all data, as one of the hottest buzzwords of our time - which might additionally help getting the external funding required to establish and maintain such a global small molecule bioavailability database. 😉)
Such a multidimensional database of physical chemical parameters for small molecules (broadly defined) could potentially be very useful for approximating physical chemical parameters for novel molecular entities - but obviously only if a LOT of nonconfidential entries were added to the database.
What do you think? Would it “fly”?
Might your senior management be willing to allow you to share your nonconfidential physical chemical parameters into such a multidimensional database?
I’m not a medicinal chemist myself, I’ve just picked up a number of such concepts over the years of interacting closely with hardcore medicinal chemists. So it would be great to hear from you guys whether you even think such a multidimensional database including calculated polar surface areas together with more traditional physical chemical properties is even worth it!
It was our pleasure to have the GEMÜ Group team at #ACHEMA24 in June! 🙌