Broad Institute of MIT and Harvard’s Post

Lifestyle Intervention with Healthy Diet, Regular Exercise, No smoking can be a Great Preventive and Therapeutic tool in Modifying Risk factors for CAD. #wellness #exercise #health #MHealth #HealthTalk #MedEd #healthcare #mindfullness #healtheducation #healthit

Epigenetics -> influence on genetic expressions Impressive study revealing lifestyle modifications reducing risk of CAD. Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence. #lipids #cholesterol #coronaryarterydisease #journal #medical #study #education #jama #lifestyle

Treating patients with superficial venous thrombosis? Than most likely you work in primary care and often feel doubt on whether or not to treat these patients with anticoagulants. Yes, there is a small yet substantial risk of #deepveinthrombosis and #pulmonaryembolism, but also likely most patients fare well without anticoagulants and 'watchful waiting'. We recently conducting a systematic review and meta-analysis on this topic, published now online in #bmjopen; here is what we found: - Evidence is poor, high variability among studies, poor methods - From what we found, high age, male sex, history of VTE, cancer and absence of varicoses seem to predict clot propagation - Multivariable models of high quality are needed; we are currently underway with such a study in primary care date, so keep tuned! Circulatory Health UMC Utrecht Florien van Royen Frans Rutten Sander van Doorn Maarten van Smeden Want to read more? See link: https://lnkd.in/eSfNgc2A

Researchers may soon be able to predict cardiovascular disease – such as atrial fibrillation and heart failure – in patients by using artificial intelligence (AI) to examine the genes in their DNA https://bit.ly/3pRG4W6 #ai #artificialintelligence #medicine

Researchers at MIT are thinking outside the box with a new long Covid, chronic Lyme disease study. Dr. Mikki Tal is heading the MIT MAESTRO research study, which is looking into potential sex differences, predictive diagnostics and immunological, neurological and other mechanisms of chronic illness. (MIT MAESTRO is based at the MIT Department of Biological Engineering and MIT's Center for Gynepathology Research.) Her team is also investigating immune-pathogen interactions, and the connection between these infections and disorders that often accompany them such as mast cell activation. They’ll also be looking at the impact of toxin exposure, connective tissue damage and gynecological implications of chronic illness. These are all issues that will resonate with patients with long Covid and chronic Lyme disease. It’s very encouraging to see researchers with an understanding of Lyme disease that reflects the reality that many patients experience when dealing with Lyme disease. #longCOVID #lymedisease #mastcellactivation https://lnkd.in/emjR-sT5

#Fibrosis is a key pathophysiological process that underlies the progression of numerous chronic and potentially life-threatening conditions affecting vital organs, such as the #heart, #liver, #lungs, and #kidneys. For years, we've heard that 45% of global deaths are due to fibrotic diseases, but this assumption has always lacked solid epidemiological backing. If, like me, you have longed for an evidence-based assessment, then look no further and delve into our Letter in the Journal of Translational Medicine, where we provide an evaluation based on the 2019 Global Burden of Disease study. https://lnkd.in/exrHMPjd

🌍 Healing Beyond Boundaries with Santex Healthcare 🏥💙 Santex's healthcare solutions know no bounds! 🌟 We transcend limits, embracing diverse therapeutic areas – from oncology and cardiology to neurology and infectious diseases. Wherever the need for healing exists, Santex is there, breaking barriers for a healthier future. 💪 Oncology Warriors: Join us in the fight against cancer, where innovation meets compassion. Together, we're pushing the boundaries of what's possible. ❤️ Cardio Care: From heart health to cardiovascular excellence, Santex Healthcare is your partner in every beat. Let's create a healthier rhythm for life. 🧠 Neurological Breakthroughs: Explore new frontiers in neurology with Santex. Our solutions aim to improve lives, one neurological advancement at a time. 🦠 Infectious Diseases Defense: In the face of challenges, Santex is at the forefront of infectious diseases defense. Let's build a healthier and safer world together. Partner with us and experience healing beyond boundaries! #HealingBeyondBoundaries #SantexHealthcare #HealthInnovation #MedicalBreakthroughs #HealthierFuture

⛱ Whether you’re already on holiday or still at work, #RareABCs is here to keep you learning and raising awareness for #rarediseases this summer. This week we continue the alphabet with the letter U! 😎   🔤 U is for Usher syndrome.   Usher syndrome is a rare ciliopathy characterized by sensorineural hearing loss (presenting at birth or in childhood), retinitis pigmentosa (RP; first presenting with night blindness and tunnel vision, with vision loss progressing over time) and, in some patients, vestibular dysfunction (issues with balance). 👁 👂 Ciliopathies are genetic diseases caused by mutations in genes involved in the structure or signaling of cilia. Cilia are hair-like organelles that provide important sensory and mechanical functions to our cells. Usher syndrome is a clinically and genetically heterogeneous disease with three distinct clinical subtypes: Usher syndrome types 1, 2 and 3 (see slides for more details). 👉 Want to learn more about this disease?   I’ve listed the best places to find information (and my sources), including ERN-EYE and Filière SENSGENE as well as various patient organizations.   📢Feel free to share this post to raise awareness for Usher syndrome!   ⚠️ Please note: the information contained in Rare ABCs is carefully researched and prepared by myself, but it is in no way intended to replace medical advice. It is a starting point to share some basic information about a specific rare disease and, if interested, provides ideas on where to find additional reliable resources and publications in order to learn more about the rare disease in question. Retina France Usher Syndrome Ireland Usher Syndrome Coalition   #ushersyndrome #healthcommunications #medicalcontent #retinitispigmentosa #ushersyndromeawareness #raiseawareness

" In this review, we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination, how mitophagy maintains mitochondrial homeostasis at the system levels and organ, and what alterations in mitophagy are related to the development of diseases, including neurological, cardiovascular, pulmonary, hepatic, renal disease, etc., in recent advances. Finally, we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials. Research advances in signaling transduction of mitophagy will have an important role in developing new therapeutic strategies for precision medicine." 👇 🧠 Wang, S., Long, H., Hou, L. et al. The mitophagy pathway and its implications in human diseases. Sig Transduct Target Ther 8, 304 (2023). https://lnkd.in/dHvKiiFA

In the realm of neurodegenerative diseases, Alzheimer's disease (AD) presents a labyrinth of molecular complexity and genetic influences that challenge our understanding and therapeutic strategies. A fantastic study led by Melanie T. Odenkirk et al., published in the Journal of Proteome Research (2024), takes us a step closer to deciphering this complexity by elucidating the intricate relationship between ApoE genotype and its proteomic and lipidomic signatures across distinct brain regions in AD. This study meticulously analyzed post-mortem brain samples from 62 individuals, balancing the number of ε4 allele carriers to explore the molecular underpinnings of AD with an unprecedented level of detail. By comparing lipid and protein alterations in the frontal cortex (FCX) and cerebellum (CBM) between AD patients and controls, Odenkirk and colleagues have highlighted the pivotal role of mitochondrial dysfunction and cell proteostasis in AD pathophysiology, underscored by the influence of ApoE polymorphism. The findings underscore a critical narrative in AD research: the presence of the ApoE ε4 allele not only exacerbates the disease’s molecular alterations but also paints a complex picture of region-specific pathologies. This study stands as a testament to the necessity of integrating genetic insights into the molecular exploration of neurodegenerative diseases, propelling us towards a future where personalized medicine could offer hope to those afflicted with AD. As we delve deeper into the genetic underpinnings of AD, studies like this are invaluable. They not only expand our understanding of the disease’s molecular basis but also pave the way for genotype-targeted therapeutic strategies. The work ahead to unravel AD’s molecular intricacies is vast, but with each study, we inch closer to a future where Alzheimer's is no longer an inscrutable enigma but a manageable condition. #AlzheimersResearch #Proteomics #Lipidomics #NeurodegenerativeDiseases #GeneticsInMedicine #PersonalizedMedicine https://lnkd.in/e8DUhMqE