Broad Institute of MIT and Harvard’s Post

📣TODAY, at noon, join us for the introduction to the series on Navigating the Use of Population Descriptors in Human Genetics and Genomics Research. Register to gain insights from this conversation! Register Now: https://lnkd.in/eibK6JBp #ASHG #HumanGenetics

Here, using hidden Markov modeling, investigators describe 74 multiallelic regions, with the remaining 86% of the genome showing lower variability, albeit with single-nucleotide polymorphisms #SNP. They demonstrate that #CMV diversity is influenced by two distinct evolutionary forces. A founder effect results in geographical segregation affecting the regions of low variability and 32 variable regions. In contrast, the 42 remaining regions, which are enriched for immunomodulatory functions, show so-called balancing selection, resulting in maintenance of equal allele frequencies irrespective of geography. These insights into CMV evolution are likely to provide insights into #virusbiology and inform the #development of #drugs and #globalvaccines. https://lnkd.in/gsxz6Gzd

💡 Day 3 Public Health #Genetics and #Genomics Week ➡ What are Public Health Genetics and Genomics Programs? Public health genetics and genomics programs are implemented from the community to the federal level to help combine genetics into clinical care and assist patients in getting access to genetic testing, counseling, and other genetic services. Learn more ⬇ #PHGW

New research in the world of genomics! 🧬A fully phased and well-annotated diploid human genome from a Han Chinese male individual (CN1) has been presented, achieving telomere-to-telomere (T2T) level assemblies. This analysis of Chentao Yang et al. reveals the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies. This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. Read the full paper here: https://lnkd.in/dgwEESCt #Genomics #ResearchPaper #ScienceDiscoveries

Addressing TRC Calls to Action is a vital responsibility in the #genomics community. We are proud to support projects like Sing Canada, Silent Genomes and more to advance Indigenous genomics in Canada. 📲 https://bit.ly/45o8aY2 Genome British Columbia Genome Alberta Genome Prairie Ontario Genomics Génome Québec Genome Atlantic

Humans and tails..... Think you could make use of a tail or are you particularly glad that humans don't? 🤣 When considering the theory of evolution, the question begs why monkeys typically have tails yet apes and even humans do not. Well Biologists from The Broad Institute of Cambridge, Massachusetts have discovered the likely cause for this genetic change is a small stretch of DNA called Alu Elements. Check out the article below for the full hypothesis and research that has gone into their suggestion:

Call for Papers! The Journal of Clinical Genetics and Heredity is seeking articles related to novel findings on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Follow us: https://lnkd.in/dd-AwMD8 Interested in submitting? Authors can submit their ready manuscripts as an attachment to Submit here: Clinicalgenetics@journalmapsci.org #genetic #heredity #research #genes #genomics #mutation #submissions #openaccess

Reading chapters 1 and 2 of "Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field" gave me and my #IADEP scholars a good review of how terminology has evolved throughout the years and a great look at the vocabulary that is acceptable for modern day health and genetic research.

Addressing health system inequities through #genomics is essential as we shift to a #PrecisionHealth future. Learn how the Canadian Genomics Enterprise is supporting research working towards health equity 👉🏽 https://bit.ly/3sdw36y #InclusiveGenomics #GenomicsForAll Genome British Columbia Genome Alberta Genome Prairie Ontario Genomics Génome Québec Genome Atlantic