argenx’s Post

🔬 Mayo Clinic Laboratories: Advancing Neurology Diagnostics 🔬 In a world of ever-faster technical change, Mayo Clinic Laboratories is uniquely positioned to innovate. Our collaboration with clinicians pinpoints unmet patient needs and facilitates the development of diagnostic testing that provides answers. 🧪 Phage Immunoprecipitation Sequencing: A Game-Changer 🧪 In our Advanced Diagnostics Laboratory, researchers are tirelessly innovating, working on numerous projects to shape the future of diagnostic treatment. One innovative approach is the use of Phage Immunoprecipitation Sequencing to discover new serological biomarkers for autoimmune diseases. 🔍 Discovering New Biomarkers: A Case Study 🔍 Recently, with PhIP-Seq, we identified a previously unknown antibody marker for immune-mediated rippling muscle disease (iRMD). This discovery, published in JAMA Neurology, will aid physicians in accurate diagnosis and patient care. 🤝 Team-Based Collaboration for Breakthroughs 🤝 Dr. John Mills, co-director of Mayo Clinic’s Neuroimmunology Laboratory, emphasizes the importance of teamwork in pioneering this technology. Our multidisciplinary approach is what drives innovation and benefits patients. Mayo Clinic Laboratories is backed by the knowledge and expertise of over 160 consultants and 4,000 employees across 60 specialty-dedicated labs. We're committed to paving the way for future discoveries that benefit patients. The future application of this technology is vast, from discovering antibodies for cancer to exploring neurological and rheumatological disorders. Our commitment to making discoveries and translating them into solutions for patients is critical to our mission. Stay tuned for more innovations and discoveries from Mayo Clinic Laboratories! #MayoClinic #NeurologyDiagnostics #MedicalInnovation #MayoClinicLab #Neurology #Innovation #diagnostics #MedicalAdvancements #multiplex https://lnkd.in/dbuNqM8d

Dive into the future of neurological diagnostics! Join our webinar on Biofluid-based Biomarkers, unlocking the potential to enhance disease diagnosis and treatment monitoring. Learn about the power of sensitive assays for accurate neurodegenerative insights. #Neuroscience #Biomarkers

Dr. Yi-Ming Chen is currently the Director of the Division of Translational Medicine in the Department of Medical Research at Taichung Veterans General Hospital. Dr Chen has wide-ranging research interests, primarily focusing on the safety of biological therapy for #autoimmune diseases, signal transduction in #rheumatology, immunology, and geriatric rheumatology. His research has also been published in leading peer-reviewed journals, including Annals of the Rheumatic Diseases. More about the Speakers: https://lnkd.in/dvBy9eTQ #arthritis #autoimmune #jointpain #vasculitis #fibromyalgia

📣 Call for Papers: Special Issue on "Immunobiology of Dendritic Cells" 📣 We are excited to announce the upcoming Special Issue on "Immunobiology of Dendritic Cells," guest-edited by the esteemed Jinming Han. Dendritic cells, the remarkable antigen-presenting cells, lie at the forefront of innate and adaptive immune responses. 🔬 Explore the World of Dendritic Cells 🔬 This exclusive issue aims to unravel the fascinating world of dendritic cells, providing a comprehensive overview of immunobiology of dendritic cells from basic to translational and clinical aspects. Recent breakthroughs in single-cell technologies have revolutionized our understanding of dendritic cell classification and functions. 💊 Translational Insights for Clinical Benefits 💊 Join us on an extraordinary journey through cutting-edge research, as we explore how dendritic cells offer promising therapeutic targets for immune disorders. With novel immunotherapies on the horizon, understanding dendritic cells may pave the way for potential clinical benefits. 📜 Submit Your Manuscripts Today! 📜 We welcome high quality manuscripts from diverse fields such as physiological and pathophysiological roles of dendritic cells, novel approaches to treat immune disorders by targeting dendritic cells. 🔑 Keywords: Dendritic cells; Cell therapy; Disease 📅 Submission Deadline: October 08, 2023 Don't miss this unparalleled opportunity to contribute to our comprehensive overview of the immunobiology of dendritic cells. Together, let's advance our knowledge and explore the potential of dendritic cells in transforming the landscape of immunology. For submission guidelines and further information, visit: https://lnkd.in/g8yngrZB #DendriticCells #Immunobiology #CellTherapy #SpecialIssue #CallForPapers #ResearchOpportunity #Immunology

B𝗹𝗼𝗼𝗱 𝘁𝗲𝘀𝘁 𝗳𝗼𝗿 𝗣𝗮𝗿𝗸𝗶𝗻𝘀𝗼𝗻'𝘀 𝗱𝗶𝘀𝗲𝗮𝘀𝗲! Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. The search for reliable biomarkers is crucial to understanding the spectrum of neurological disease, randomized clinical trials, screening and diagnosis and prognosis.  Earlier this year, researchers have reported the possibility of detecting in spinal fluid a misfolded form of a neural protein called α-synuclein, the pathological hallmark of Parkinson's disease, in patients. 👉 The new test proposed by the authors of the study published in Science Translational Medicine is based on the observations that PD often involves malfunctioning mitochondria. Indeed, specific brain region with accumulation of mitochondrial DNA (mtDNA) damage has been identified  in PD animal models, as well as in human PD postmortem brain tissue. The strategy of the authors was to quantify mtDNA damage in blood from patients . 📣 The authors have developed a PCR-based assay (Mito DNADX) that allows for the accurate real-time quantification of mtDNA damage in a scalable platform.  In this preliminary study, the test was able to distinguish several sets of up to about 50 people with Parkinson’s disease from healthy control subjects. Further, according to the authors,  this test could also flag people before they develop serious disease.  #parkinson's disease #neuroscience #biomarker #PCR #medicine

👀 Are you looking to enhance your preclinical research with the use of large animals like pigs and NHP? 🐒 🐖 📲 Reach out to me today to explore how we can elevate your projects 🔬 🎯 #preclinical #outsourcing #pigs #monkey #preclinicalresearch PreClinic Pharmacology Services

We are thrilled to #announce the publication of our latest research article titled "The potential role and mechanism of circRNAs in Ferroptosis: a comprehensive review" in the esteemed journal,Pathology Researchand Practice, Impact Factor: 2.8. This #comprehensive_review delves into the intriguing world of #cell #death #mechanisms, with a particular focus on Ferroptosis - a unique, #iron_dependent form of regulated #cell_death distinguished by its reliance on reactive oxygen species (#ROS) and distinct from other forms such as #necrosis and #apoptosis. Our study highlights the crucial regulatory roles of circular #RNAs #(circRNAs) within ferroptosis-mediated pathways, underscoring their significance in #diseases linked to ferroptosis including #cancer, #neurological, and #cardiovascular diseases. Through our research, we offer new insights into the #diagnosis, #treatment, and #prognosis of ferroptosis-related diseases, emphasizing the therapeutic implications of targeting circRNAs in cancer treatment and the modulation of ferroptosis #pathways. This opens up novel avenues for advancements in disease management and highlights the potential of circRNAs as both #diagnostic markers and #therapeutic targets. A heartfelt thank you to my co-authors Kimia Rezaei, Javad Yaghmoorian Khojini, Shokufeh Razi, and Mohammad Javad Hayati, and our corresponding author Seyed Mohammad Gheibihayat, for their invaluable contributions. We extend our gratitude to Elsevier and Urban & Fischer for their support and for providing a platform for our #research. We #invite our peers, colleagues, and anyone interested in the cutting-edge developments in #cellular #biology and #disease management to #read and #share our findings. Your support and engagement are immensely appreciated as we continue to explore and understand the complexities of life at the molecular level. #Ferroptosis #circRNAs #CellDeath #cancer #CancerResearch #Neurology #CardiovascularDisease #PathologyResearch #Elsevier #SciencePublication

In #BreakingNews in the Alzheimer's Disease space, Roche is granted breakthrough device designation for its Alzheimer's Disease diagnostic blood test, Elecsys pTau217. The test was co-developed with Eli Lilly and Company, and is described to "works to identify the presence or absence of amyloid pathology". In short, a positive 'pTau217' plasma biomarker presence would indicate "high likelihood of having a positive amyloid positron emission tomography (PET)/cerebrospinal fluid (CSF) result" and will allow earlier diagnosis and interventions. https://lnkd.in/eAAs629q #AlzheimersDisease #Roche #EliLilly #NeurodegenerativeDisease #Neurology #Neuroscience #Innovation #Breakthroughs #Biomarkers #Diagnostics #RegulatoryAffairs #Pharma #Healthcare

📣 Call for Papers: Special Issue on "Immunobiology of Dendritic Cells" 📣 We are excited to announce the upcoming Special Issue on "Immunobiology of Dendritic Cells," guest-edited by the esteemed Jinming Han. Dendritic cells, the remarkable antigen-presenting cells, lie at the forefront of innate and adaptive immune responses. 🔬 Explore the World of Dendritic Cells 🔬 This exclusive issue aims to unravel the fascinating world of dendritic cells, providing a comprehensive overview of immunobiology of dendritic cells from basic to translational and clinical aspects. Recent breakthroughs in single-cell technologies have revolutionized our understanding of dendritic cell classification and functions. 💊 Translational Insights for Clinical Benefits 💊 Join us on an extraordinary journey through cutting-edge research, as we explore how dendritic cells offer promising therapeutic targets for immune disorders. With novel immunotherapies on the horizon, understanding dendritic cells may pave the way for potential clinical benefits. 📜 Submit Your Manuscripts Today! 📜 We welcome high quality manuscripts from diverse fields such as physiological and pathophysiological roles of dendritic cells, novel approaches to treat immune disorders by targeting dendritic cells. 🔑 Keywords: Dendritic cells; Cell therapy; Disease 📅 Submission Deadline: October 08, 2023 Don't miss this unparalleled opportunity to contribute to our comprehensive overview of the immunobiology of dendritic cells. Together, let's advance our knowledge and explore the potential of dendritic cells in transforming the landscape of immunology. For submission guidelines and further information, visit: https://lnkd.in/gAW_UHFz #DendriticCells #Immunobiology #CellTherapy #SpecialIssue #CallForPapers #ResearchOpportunity #Immunology

Vaxxinity, unveiled intriguing findings at the 2024 American Academy of Neurology conference concerning their investigational active immunotherapy, UB-312. The study aimed to assess target engagement in cerebrospinal fluid (CSF) samples of Parkinson's disease (PD) patients using the Amprion R&D aSyn seed amplification assay (aSyn-SAA). UB-312 represents a promising direction in PD treatment by targeting pathological forms of alpha-synuclein (aSyn), a pivotal protein linked to the advancement of synucleinopathies. Unlike traditional methods, UB-312 endeavors to stimulate antibodies that specifically identify and counteract these detrimental aSyn variants, potentially arresting or decelerating the neurodegenerative mechanisms underlying PD. Read more @ https://lnkd.in/gEBn5M8f #Vaxxinity #UB312 #ParkinsonsDisease #NeurologyConference #Immunotherapy #AlphaSynuclein #CSFsamples #Neurodegeneration #Synucleinopathies #PDResearch