Sr. Scientist, Extrahepatic Targeting
Sr. Scientist, Extrahepatic Targeting
Arrowhead Pharmaceuticals
San Diego, CA
See who Arrowhead Pharmaceuticals has hired for this role
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The successful candidate will work in an interdisciplinary discovery team focusing on extrahepatic targeting. She/He will be an innovative leading scientist with the ability to work independently and collaboratively, design and carry out experiments and propose creative solutions to challenging problems.
Responsibilities
$140,000—$170,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
California Applicant Privacy Policy
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The successful candidate will work in an interdisciplinary discovery team focusing on extrahepatic targeting. She/He will be an innovative leading scientist with the ability to work independently and collaboratively, design and carry out experiments and propose creative solutions to challenging problems.
Responsibilities
- Design and execute in vitro and in vivo studies to facilitate drug discovery and platform development in various disease areas
- Develop, validate, and perform assays to characterize ligand-receptor interactions and to gain mechanistic understanding of drug delivery
- Present research findings to project teams and governance bodies and prepare study reports
- Maintain a high level of productivity in the lab and perform critical experiments
- Guide junior scientists on the team
- PhD in biology, bioengineering, biochemistry, or a related field with at least 5 years of relevant experience in biotech or pharmaceutical industry
- Expertise in developing endpoint & kinetic assays, such as luminescence & fluorescence assays, activity assays, imaging-based assays
- Strong background in characterization of ligand-receptor interactions using molecular, cellular, and biochemical approaches
- Experienced in RNA isolation, real-time PCR, RNA-seq
- Hands-on experience with cell culture and FACS cell sorting
- Ability to adapt well to fast changing goals and research directions
- Proven scientific accomplishments including publications, conference presentations or patents
- Knowledge and experience with protein sciences
- Familiarity with various therapeutic areas
$140,000—$170,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
California Applicant Privacy Policy
-
Seniority level
Mid-Senior level -
Employment type
Full-time -
Job function
Research, Analyst, and Information Technology -
Industries
Pharmaceutical Manufacturing
Referrals increase your chances of interviewing at Arrowhead Pharmaceuticals by 2x
See who you knowGet notified about new Senior Scientist jobs in San Diego, CA.
Sign in to create job alertSimilar jobs
People also viewed
-
Senior Research Associate - Senior Scientist, In-Vivo Editing
Senior Research Associate - Senior Scientist, In-Vivo Editing
-
Senior Chemist
Senior Chemist
-
Senior Scientist, Discovery
Senior Scientist, Discovery
-
Senior R&D Bakery Scientist
Senior R&D Bakery Scientist
-
Senior Chemist
Senior Chemist
-
Scientist
Scientist
-
Senior Scientist
Senior Scientist
-
Senior Scientist, Antibody Expression & Characterization
Senior Scientist, Antibody Expression & Characterization
-
Associate Scientist
Associate Scientist
-
Senior Scientist II, High-Throughput DNA Production
Senior Scientist II, High-Throughput DNA Production
Looking for a job?
Visit the Career Advice Hub to see tips on interviewing and resume writing.
View Career Advice Hub