Research Associate II, Biology

Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco.

Visit https://lyciatx.com/ for more information.

Position Summary:

Lycia Therapeutics is seeking a motivated and versatile Research Associate II in the Biology group to develop and execute cell biology, immunological, and protein binding assays to support pipeline and partnered projects. The associate will work closely both with members of the biology team and across functional groups as part of an innovate research organization to help advance molecules to the clinic

Key Responsibilities:

• Generate high quality, reproducible data with antibody and small molecule conjugates to support pipeline project advancement and further development of the LYTAC platform
• Design, optimize and execute cell-based assays and protein-binding assays to characterize and evaluate novel therapeutics and understand mechanism of action
• Analyze in vivo samples from PK, PD and efficacy studies using immunoassays
• Evaluate, interpret, and document scientific results and communicate findings
• Collaborate with chemistry and biologics scientists in cross-functional project teams to progress drug discovery and drug development efforts
  
  
  

Required Education and Experience:

• BS or MS in cell biology, molecular biology, biochemistry, immunology, or related field with 0-3 years of relevant experience. Title will be commensurate with years of relevant experience
  
  
  

Additional Qualifications:

• Proficiency in mammalian cell culture and cell-based assays using flow cytometry, luminescence or other methods
• Expertise conducting immunoassays (e.g. ELISA, MSD or Luminex)
• Experience with biochemical/biophysical methods to measure protein binding or enzymatic activity
  
  
  

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

The expected base salary range for this role is $85 - 100k. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications and internal equity. Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.