Shih-chu Kao

All-optical phase conjugation using diffractive wavefront processing https://lnkd.in/gcC8KQF2 UCLA Henry Samueli School of Engineering and Applied Science California NanoSystems Institute at UCLA ECE Department UCLA Bioengineering #diffractiveprocessors

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What cancer clinical treatment cut the risk of death by more than half? A two months increase in life span is usually heralded. The combination of Kytruda (Merck) that enhances the immune response generally, and Padcev (Seattle Genetics), an antibody to nectin-4 that is over expressed in cancer cells, conjugated to a cell division disrupter, did just that for bladder cancer (Nature 623,p.231, 2023). The latter drug is a biotechnology Antibody Drug Conjugate (ADC). See also the blog https://lnkd.in/gaN_WB8F

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CyVerse.Org, an open science platform led by the University of Arizona, will provide the computing infrastructure for a new center focused on molecular and cellular biosciences that has received a $20 million award from the U.S. National Science Foundation (NSF) Tyson Swetnam, director of the Open Science Initiative at Arizona's Institute for Computation and Data-Enabled Insight, highlights that CyVerse is the plumbing for these projects that involve enormous data sets. It provides a trans-institutional, open-source framework that helps researchers collaborate on national-scale projects like the Synthesis Centers to solve the planet's greatest challenges. CyVerse offers computation, data storage, and training in advanced data science techniques, breaking barriers to large-scale information synthesis. "Being part of the two recent NSF Synthesis Centers affirms the collaborative role CyVerse and the University of Arizona play in providing key infrastructure that allows communities to effectively address complex questions." Nirav Merchant, director of the Data Science Institute https://bit.ly/3w7yBp4

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Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer https://lnkd.in/eQznpUBu

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🧬🔍 SCOTCH: Single-Cell Omics for Transcriptome CHaracterization 🧫📊 Presented in a recent bioRxiv article by Zhuoran Xu, Hui-Qi Qu, Joe Chan, Charlly Kao, Hakon Hakonarson, and Kai Wang. SCOTCH uses long-read single-cell RNA for isoform-level characterization and novel isoforms discovery. 📝 Key Highlights: 🚀 SCOTCH overcomes the limitations of short-read sequencing by employing long-read technologies, enabling thorough analyses of complex genomic regions and precise isoform identification. 🧑‍🔬 Compatible with library preparation platforms from 10X Genomics and Parse Biosciences, and is versatile across diverse cell types such as neurons, hepatocytes, and developing cardiomyocytes. 📈 Differential isoform usage across cell populations, shedding light on cellular functions and disease mechanisms that go beyond traditional gene-level expression analysis. 📚 bioRxiv paper: https://buff.ly/44FsyVx 👨‍💻 GitHub: https://buff.ly/44CEes2 📢 Join the Conversation 📢 Share your ideas, methods, and tools in the comments! 👇 💬 #SingleCellOmics #Transcriptomics #Genomics #Bioinformatics #SCOTCH #BiotechInnovation #PharmaLeaders

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Unlock the secrets of gene regulation! This exciting article, https://lnkd.in/gPe6AUKY, demonstrates single-cell multiplex profiling of gene expression and RNA–chromatin associations within individual nuclei. It uncovers cellular heterogeneity in chromatin architecture and its correlation with gene regulation, aging, and disease pathology in the human brain. Explore how chromatin-associated RNA influences gene expression spatially with our advanced Multiomic assay. You can jointly visualize RNA and chromatin-associated proteins in the same section. #multiomics #spatial #ageing #generegulation Learn more here: https://lnkd.in/gB9GVuJb

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Delpacibart Etedesiran, or AOC 1001 developed by Avidity Biosciences, Inc., receives FDA Breakthrough Therapy Designation for for Treatment of Myotonic Dystrophy Type 1. AOC 1001 consists of a mAb that binds to the transferrin receptor 1 (TfR1) conjugated with a small interfering RNA (siRNA) targeting DMPK mRNA. This allows the drug to address the underlying cause of disease by reducing DMPK mRNA, potentially alleviating the spectrum of symptoms that people with DM1 experience. The 2024 Annual Conference of our society is just around the corner, scheduled to take place in Cambridge, MA, USA on Saturday, May 11, 2024. Don’t miss out on this exceptional opportunity to network with experts from both academia and industry, register through the following link https://lnkd.in/ecmFPA4v #antibodydiscovery #immunology #oncology #annualmeeting #annualconference #antibodies #mab #mabs #mrna #aoc  #myotonicdystrophytype1 https://lnkd.in/ggytKY-a

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Check out our very own computational visionary KyungHyun Cho give his Keynote Talk at this year's #ICLR2024. #artificialintelligence #machinelearning #deeplearning #generativeAI #nlp #llms #computationalbiology #computerscience #drugdiscovery #medicine #weareroche

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🚀 Exciting Insights from EBMT Roundtable! 🚀 Join us as we dive into the latest findings on the efficacy and safety of Allo HSCT and CAR T Cell Therapy in pediatric leukemia patients, brought to you by Professor Shaoyan Hu's team. 🌟👩‍🔬👨‍🔬 This groundbreaking discussion at the EBMT Roundtable highlights innovative approaches and promising results in pediatric leukemia treatment. Don’t miss out on these crucial advancements in medical science! 🧬🔬 📺 Watch now and stay informed on the future of leukemia therapy! #LeukemiaResearch #PediatricOncology #CAR_TCellTherapy #AlloHSCT #MedicalInnovation #EBMT2024 #CancerTreatment #MedicalBreakthroughs #ProfessorShaoyanHu #HealthcareAdvancements #OncologyUpdates

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BacStich DNA CSO Sasha Levy, PhD, is at SynBioBeta's Synthetic Biology Conference in San Jose this week to speak on the MITRE sponsored panel "BioNet: Creating a Distributed SynBio Ecosystem for Everyone" on May 8th from 1:45-2:30. Come by and say hi! SynBioBeta MITRE #syntheticbiology #dnasynthesis

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Check out this recent Nature paper from the Gleeson lab, UCSD https://lnkd.in/eWG5GPJ2 Simultaneous genome & transcriptome profiling of single nuclei from brain tissue samples 🧠 uncovering lineage relationships #singlecell #multiomics #genomics #transcriptomics

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#ICYMI: Last month we announced that we raised $132.5 million in an oversubscribed #SeriesC financing to advance our pipeline of potential therapies for fibrotic lung diseases and oncology. We are thankful for the support of our investors, board, #biotech community and the entire Endeavor BioMedicines team.     In this BioSpace article, get more details about what this financing means for the future of our pipeline and our goal to restore hope for patients with life-threatening diseases: https://bit.ly/4aVqAmo    #biotechnews #fundraising #venturecapital #oncology #lungdiseases

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In development: Low molecular weight DNA extract input fragmentation on Fire Monkey magnetic beads for long Oxford Nanopore Technologies reads. https://lnkd.in/eiHCBUFP

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If you are attending #ESHG2024 you are most welcome to meet me at my poster at the session this afternoon. Find out more about the science and applications made possible by Quantum-Si technology!

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In this new published article, we present a numerical analysis for the inference of mechanisms of bacterial cell division. Check it up! https://lnkd.in/eYbab54A

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https://lnkd.in/gFywNvYx A great book to read if you are interested in learning about Biophotonics and Biosensing. This book provides fundamental insights into optical biosensors and their applications in biomedical sciences. Discusses signal and image processing algorithms, including the latest advancements in artificial intelligence approaches.

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In this episode of #LungCancerConsidered, host Dr. Stephen Liu discusses KRAS mutant #NSCLC, focusing on non-G12C mutations. KRAS mutations are very common in #lungcancer and while there are now multiple approved and active KRAS inhibitors, they are specifically for the G12C mutation. Newer strategies are needed for other common mutations such as KRAS G12V and G12D and fortunately, new drugs are on the horizon. With guests Dr. Rajwanth R. Veluswamy, from Mount Sinai and Dr. Mariana Brandao, from the University of Brussels. Listen: https://bit.ly/24KRASG12C #LCSM

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