About
Activity
-
I'm excited to be keynoting this years PyCon Uganda! Love the African Python community and looking forward to sharing ❤️
I'm excited to be keynoting this years PyCon Uganda! Love the African Python community and looking forward to sharing ❤️
Liked by Niels Bantilan
-
Meta's PyTorch teams published their actual roadmap documents publicly for the first time: https://lnkd.in/eVv7ychp Our engineers' incentives and…
Meta's PyTorch teams published their actual roadmap documents publicly for the first time: https://lnkd.in/eVv7ychp Our engineers' incentives and…
Liked by Niels Bantilan
-
How do we turn the often overlooked task of documentation into an engaging, productive, and even fun activity? I've just shared a blog post…
How do we turn the often overlooked task of documentation into an engaging, productive, and even fun activity? I've just shared a blog post…
Liked by Niels Bantilan
Experience & Education
Licenses & Certifications
-
Deep Learning Specialization
Coursera Course Certificates
-
-
-
-
-
-
-
-
Publications
-
Themis-ml: A Fairness-aware Machine Learning Interface for End-to-end Discrimination Discovery and Mitigation
ArXiv
Themis-ml is a Python library built on top of pandas and sklearn that implements fairness-aware machine learning algorithms. This paper provides the context, motivation, and high-level technical specification of an application programming interface that helps research and product teams to measure and reduce potential discrimination in their dataset and algorithms.
-
Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse
Science Signaling
Polarization of the T cell microtubule–organizing center (MTOC) to the immunological synapse between the T cell and an antigen-presenting cell (APC) maintains the specificity of T cell effector responses by enabling directional secretion toward the APC. The reorientation of the MTOC is guided by a sharp gradient of the second messenger diacylglycerol (DAG), which is centered at the immunological synapse. We used a single-cell photoactivation approach to demonstrate that diacylglycerol kinase α…
Polarization of the T cell microtubule–organizing center (MTOC) to the immunological synapse between the T cell and an antigen-presenting cell (APC) maintains the specificity of T cell effector responses by enabling directional secretion toward the APC. The reorientation of the MTOC is guided by a sharp gradient of the second messenger diacylglycerol (DAG), which is centered at the immunological synapse. We used a single-cell photoactivation approach to demonstrate that diacylglycerol kinase α (DGK-α), which catalyzes the conversion of DAG to phosphatidic acid, determined T cell polarity by limiting the diffusion of DAG. DGK-α–deficient T cells exhibited enlarged accumulations of DAG at the immunological synapse, as well as impaired reorientation of the MTOC. In contrast, T cells lacking the related isoform DGK-ζ did not display polarization defects. We also found that DGK-α localized preferentially to the periphery of the immunological synapse, suggesting that it constrained the area over which DAG accumulated. Phosphoinositide 3-kinase activity was required for the peripheral localization pattern of DGK-α, which suggests a link between DAG and phosphatidylinositol signaling during T cell activation. These results reveal a previously unappreciated function of DGK-α and provide insight into the mechanisms that determine lymphocyte polarity.
Other authorsSee publication -
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse
The Journal of Experimental Medicine
The immunological synapse formed by a T lymphocyte on the surface of a target cell contains a peripheral ring of filamentous actin (F-actin) that promotes adhesion and facilitates the directional secretion of cytokines and cytolytic factors. We show that growth and maintenance of this F-actin ring is dictated by the annular accumulation of phosphatidylinositol trisphosphate (PIP3) in the synaptic membrane. PIP3 functions in this context by recruiting the exchange factor Dock2 to the periphery…
The immunological synapse formed by a T lymphocyte on the surface of a target cell contains a peripheral ring of filamentous actin (F-actin) that promotes adhesion and facilitates the directional secretion of cytokines and cytolytic factors. We show that growth and maintenance of this F-actin ring is dictated by the annular accumulation of phosphatidylinositol trisphosphate (PIP3) in the synaptic membrane. PIP3 functions in this context by recruiting the exchange factor Dock2 to the periphery of the synapse, where it drives actin polymerization through the Rho-family GTPase Rac. We also show that synaptic PIP3 is generated by class IA phosphoinositide 3-kinases that associate with T cell receptor microclusters and are activated by the GTPase Ras. Perturbations that inhibit or promote PIP3-dependent F-actin remodeling dramatically affect T cell cytotoxicity, demonstrating the functional importance of this pathway. These results reveal how T cells use lipid-based signaling to control synaptic architecture and modulate effector responses.
Other authorsSee publication -
Expression patterns of Oct4, Cdx2, Tead4, and Yap1 proteins during blastocyst formation in embryos of the marsupial, Monodelphis domestica Wagner.
Evolution and Development
Mouse and opossum embryos develop in quite distinct manners. While mouse embryos rely on cell-cell adhesion for 'knowing' how to structure itself during development, opossum embryos rely on cell-zona (zona is short for zona pellucida, which is the outerlayer of glycoproteins surrounding the embryo). Our study describes the expression and localization patterns of key developmental genes that fall into to broad categories: one category determines which cells eventually become the animal, and the…
Mouse and opossum embryos develop in quite distinct manners. While mouse embryos rely on cell-cell adhesion for 'knowing' how to structure itself during development, opossum embryos rely on cell-zona (zona is short for zona pellucida, which is the outerlayer of glycoproteins surrounding the embryo). Our study describes the expression and localization patterns of key developmental genes that fall into to broad categories: one category determines which cells eventually become the animal, and the other determines which cells become part of the trophoblast, an embryonic structure that performs other functions besides 'becoming the animal'.
Other authors -
Courses
-
Biological and Environmental Determinants of Health
PUBHP6040
-
Complexity Science
EAEEE9305
-
Foundations of Public Health
PUBHP6020
-
Health Systems
PUBHP6060
-
Integration of Science and Practice
PUBHP6071
-
Introduction to Computer Application to Health
BINF G4001
-
Introduction to Data Science
STATW4242
-
Leadership and Innovation
PUBHP6080
-
Machine Learning for Data Science
COMSW4721
-
Methods in Research Design and Evaluation
PUBHP6030
-
Public Health Informatics
SOSC P8779
-
Qualitative Research Design
SOSCP8785
-
Social, Behavioral, and Structural Determinants of Health
PUBHP6050
-
Structural Approaches to Global Health
SOSCP8741
Projects
-
Pandera
A dataframe validation library for scientists, engineers, and analysts seeking correctness.
-
Themis-ml
- Present
themis-ml is an open source machine learning library that implements several fairness-aware methods that comply with the sklearn API.
Languages
-
English
-
More activity by Niels
-
Being 1.0 for Polars, doesn't mean we reduce our development pace. A week later Polars 1.1 with: - Much faster parquet decoding (x1.5 improvement on…
Being 1.0 for Polars, doesn't mean we reduce our development pace. A week later Polars 1.1 with: - Much faster parquet decoding (x1.5 improvement on…
Liked by Niels Bantilan
-
Delightful piece of Developer eXperience in scikit-learn: If you use the HTML-powered output for pipelines and column transformers, you can now…
Delightful piece of Developer eXperience in scikit-learn: If you use the HTML-powered output for pipelines and column transformers, you can now…
Liked by Niels Bantilan
-
Come check out what we've been busy building at Union! We've worked really hard to incorporate the fundamentals of OSS Flyte https://lnkd.in/gGZsKS3g…
Come check out what we've been busy building at Union! We've worked really hard to incorporate the fundamentals of OSS Flyte https://lnkd.in/gGZsKS3g…
Liked by Niels Bantilan
-
I am excited to be giving a 4-hour tutorial on "Pretraining and Finetuning LLMs from the Ground Up" at the SciPy Conference in 5 days! This tutorial…
I am excited to be giving a 4-hour tutorial on "Pretraining and Finetuning LLMs from the Ground Up" at the SciPy Conference in 5 days! This tutorial…
Liked by Niels Bantilan
-
⭐️ Super excited about the Union.ai #serverless launch! ⭐️ ☁️ Union serverless provides the compute infrastructure and orchestration tools to build…
⭐️ Super excited about the Union.ai #serverless launch! ⭐️ ☁️ Union serverless provides the compute infrastructure and orchestration tools to build…
Shared by Niels Bantilan
-
It’s been a long time coming but we’re very proud to announce that Polars 1.0 just went gold! 🐻❄️⭐️ There’s another huge list of improvements, the…
It’s been a long time coming but we’re very proud to announce that Polars 1.0 just went gold! 🐻❄️⭐️ There’s another huge list of improvements, the…
Liked by Niels Bantilan
Other similar profiles
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Explore More