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BHI welcomes Bob Darin as our interim CEO. Bob brings deep industry experience, coupled with a commitment to leverage data and analytics, to improve…
BHI welcomes Bob Darin as our interim CEO. Bob brings deep industry experience, coupled with a commitment to leverage data and analytics, to improve…
Liked by John Walker
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Every data-related eBook from Packt Publishing, including my title "Data Science Projects with Python", is only $10 during the month of September as…
Every data-related eBook from Packt Publishing, including my title "Data Science Projects with Python", is only $10 during the month of September as…
Liked by John Walker
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Excited to share a collaborative blog post detailing my Insight Data Science consulting project with Manifold.co! Check out the post here on…
Excited to share a collaborative blog post detailing my Insight Data Science consulting project with Manifold.co! Check out the post here on…
Liked by John Walker
Experience & Education
Publications
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A closer look at hippocampal correlates of memory
Trends in Cognitive Sciences
Current interpretations of hippocampal memory function are blind to the fact that viewing behaviors are pervasive and complicate the relationships among perception, behavior, memory, and brain activity. For example, hippocampal activity and associative memory demands increase with stimulus complexity. Stimulus complexity also strongly modulates viewing. Associative processing and viewing thus are often confounded, rendering interpretation of hippocampal activity ambiguous. Similar…
Current interpretations of hippocampal memory function are blind to the fact that viewing behaviors are pervasive and complicate the relationships among perception, behavior, memory, and brain activity. For example, hippocampal activity and associative memory demands increase with stimulus complexity. Stimulus complexity also strongly modulates viewing. Associative processing and viewing thus are often confounded, rendering interpretation of hippocampal activity ambiguous. Similar considerations challenge many accounts of hippocampal function. To explain relationships between memory and viewing, we propose that the hippocampus supports the online memory demands necessary to guide visual exploration. The hippocampus thus orchestrates memory-guided exploration that unfolds over time to build coherent memories. This new perspective on hippocampal function harmonizes with the fact that memory formation and exploratory viewing are tightly intertwined.
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Macular carotenoids, aerobic fitness, and central adiposity are differentially associated with hippocampal-dependent relational memory in preadolescent children
The Journal of Pediatrics
Objectives
To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children.
Study design
Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via…Objectives
To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children.
Study design
Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume. Central adiposity was assessed via dual-energy x-ray absorptiometry. MPOD was measured psychophysically by the use of customized heterochromatic flicker photometry. Statistical analyses included correlations and hierarchical linear regression.
Results
Aerobic fitness and MPOD were associated negatively with relational memory errors (P < .01), whereas central adiposity was associated positively with relational memory errors (P < .05). Hierarchical regression analysis revealed that MPOD accounted for a significant amount of the variance in relational memory performance even after we accounted for aerobic fitness (β = −0.388, P = .007).
Conclusions
Even after we adjusted for aerobic fitness and central adiposity, factors known to relate to hippocampal-dependent memory, MPOD positively and significantly predicted hippocampal-dependent memory performance.Other authorsSee publication -
Hippocampal structure predicts cortical indices of reactivation of related items
Neuropsychologia
One of the key components of relational memory is the ability to bind together the constituent elements of a memory experience, and this ability is thought to be supported by the hippocampus. Previously we had shown that these relational bindings can be used to reactivate the cortical processors of an absent item in the presence of a relationally bound associate (Walker et al., 2014). Specifically, we recorded the event-related optical signal (EROS) when presenting the scene of a face-scene…
One of the key components of relational memory is the ability to bind together the constituent elements of a memory experience, and this ability is thought to be supported by the hippocampus. Previously we had shown that these relational bindings can be used to reactivate the cortical processors of an absent item in the presence of a relationally bound associate (Walker et al., 2014). Specifically, we recorded the event-related optical signal (EROS) when presenting the scene of a face-scene pair during a preview period immediately preceding a test display, and demonstrated reactivation of a face-processing cortical area (the superior temporal sulcus, STS) for scenes that had been previously paired with faces, relative to scenes that had not. Here we combined the EROS measures during the same preview paradigm with anatomical estimates of hippocampal integrity (structural MRI measures of hippocampal volume and diffusion tensor imaging measures of mean fractional anisotropy and diffusivity) to provide evidence that the hippocampus is mediating this reactivation phenomenon. The study was run in a sample of older adults aged 55–87, taking advantage of the high amount of hippocampal variability present in aging. We replicated the functional reactivation of STS during the preview period, specific to scenes previously paired with faces. Crucially, we also found that this phenomenon is correlated with structural hippocampus integrity. Both STS reactivation and hippocampal structure predicted subsequent recognition performance. These data support the theory that relational memory is sustained by an interaction between hippocampal and cortical sensory processing regions, and that these functions may be at the basis of episodic memory changes in normal aging.
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When memory leads the brain to take scenes at face value: face areas are reactivated at test by scenes that were paired with faces at study
Frontiers in Human Neuroscience
In the first use of the event-related optical signal as a brain imaging tool for the study of long-term memory, we examined relational or associative aspects of memory, widely presumed to involve the interplay among multiple brain regions in representing and reactivating different elements of a given event. Here, we found that a brain region known to be involved in face processing (the posterior superior temporal sulcus) was active not only when viewing faces during the study phase but also…
In the first use of the event-related optical signal as a brain imaging tool for the study of long-term memory, we examined relational or associative aspects of memory, widely presumed to involve the interplay among multiple brain regions in representing and reactivating different elements of a given event. Here, we found that a brain region known to be involved in face processing (the posterior superior temporal sulcus) was active not only when viewing faces during the study phase but also when viewing scenes at test that, through prior learning, were associated with specific faces. These findings, demonstrating the activation of stimulus-specific cortical regions in the absence of stimuli of that type, based on learned relations, reveal cortical substrates of the reactivation of relational memories.
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Honors & Awards
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National Institutes of Health National Research Service Award (T32)
National Institutes of Health
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National Defense Science and Engineering Graduate Fellowship
US Department of Defense
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National Science Foundation Graduate Research Fellowship
National Science Foundation
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Departmental Highest Honors
UCLA Psychology Department
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Summa Cum Laude
University of California, Los Angeles
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First Team, All-California Academic Team
Community College League of California
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