San Francisco, California, United States
Contact Info
15K followers
500+ connections
About
Articles by Jessica
Activity
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I'm throwing an epic event in the Hamptons in a few weeks! Limited invites & really just have room for VIP tech folks Comment below or DM me if…
I'm throwing an epic event in the Hamptons in a few weeks! Limited invites & really just have room for VIP tech folks Comment below or DM me if…
Liked by Jessica Karr
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Team Vitelle are semifinalists in Black Ambition and I am so proud of what we've accomplished! Thank you Kayla Doan and Paul Collins for your…
Team Vitelle are semifinalists in Black Ambition and I am so proud of what we've accomplished! Thank you Kayla Doan and Paul Collins for your…
Liked by Jessica Karr
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Are you passionate about women's health? Are you looking for the opportunity of a lifetime to build and shape the patient experience? At Gabbi we are…
Are you passionate about women's health? Are you looking for the opportunity of a lifetime to build and shape the patient experience? At Gabbi we are…
Liked by Jessica Karr
Experience & Education
Licenses & Certifications
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Registered Yoga Teacher
Stephanie Snyder and Jhon Tamayo Yoga Teacher Trainings, 500 hours
Issued
Volunteer Experience
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Volunteering Member and Swim Angel
SOUTH END ROWING CLUB
- Present 2 years 11 months
Health
The best club in the world.
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Swim Angel
Max 415
- Present 3 months
Health
Swim Angel helping new swimmers train for the swim from Alcatraz! MAX 415 is a youth lead initiative that focuses on health and well-being.
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Volunteer
GLIDE (San Francisco, CA)
- Present 9 years 5 months
Poverty Alleviation
In the heart of the Tenderloin district, helping prepare and serve meals to those in need.
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Art Assistant Volunteer
Creativity Explored
- 9 months
Arts and Culture
Assist artists with developmental disabilities.
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Co Chair
Slow Food
- 3 years 2 months
Slow Food is an idea, a way of living and a way of eating. It is a global, grassroots movement with thousands of members around the world that links the pleasure of food with a commitment to community and the environment.
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Publications
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Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes.
Current Opinions in Microbiology
The microbiome is an abundance of microorganisms within a host (e.g. human microbiome). These microorganisms produce small molecules and metabolites that have been shown to affect and dictate the physiology of an individual. Functional knowledge of these molecules, often produced for communication or defense, will reveal the interplay between microbes and host in health and disease. The vast diversity in structure and function of microbiome-associated small molecules necessitate tools that will…
The microbiome is an abundance of microorganisms within a host (e.g. human microbiome). These microorganisms produce small molecules and metabolites that have been shown to affect and dictate the physiology of an individual. Functional knowledge of these molecules, often produced for communication or defense, will reveal the interplay between microbes and host in health and disease. The vast diversity in structure and function of microbiome-associated small molecules necessitate tools that will utilize multiple '-omics' strategies to understand the interactions within the human microbiome. This review discusses the importance of these investigations and the integration of current '-omics' technologies with tools established in natural product discovery in order to identify and characterize uncharacterized small molecules in the effort towards diagnostic modeling of the human microbiome.
Other authorsSee publication -
A Hinge Region cis-Proline in Ribonuclease A Acts as a Conformational Gatekeeper for C-Terminal Domain Swapping.
Journal of Molecular Biology
Domain swapping, the process in which a structural unit is exchanged between monomers to create a dimer containing two versions of the monomeric fold, is believed to be an important mechanism for oligomerization and the formation of amyloid fibrils. Structural studies have implicated proline as an important residue for domain swapping due to its increased frequency in hinge regions preceding swapped arms. We hypothesized that prolines unique ability to populate both cis and trans peptide bond…
Domain swapping, the process in which a structural unit is exchanged between monomers to create a dimer containing two versions of the monomeric fold, is believed to be an important mechanism for oligomerization and the formation of amyloid fibrils. Structural studies have implicated proline as an important residue for domain swapping due to its increased frequency in hinge regions preceding swapped arms. We hypothesized that prolines unique ability to populate both cis and trans peptide bond conformations may allow proline to act as a conformational gatekeeper, regulating interconversion between monomer and domain-swapped dimer forms. The hinge region of RNase A contains a proline at residue 114 that adopts a cis conformation in the monomer and extends to a trans conformation in the C-terminal domain-swapped dimer. Substitution of P114 with residues that strongly prefer a trans peptide bond (Ala, Gly) results in significant population of the C-terminal domain-swapped dimer under near-physiological conditions (pH 8.0, 37°C). This is in stark contrast to dimerization of wild-type RNase A, which requires incubation under extreme conditions such as lyophilization from acetic acid or elevated temperature. In addition, we observe similar results when cis-P114 is mutated to glycine in a homologous RNase, human pancreatic RNase 1. Our results suggest isomerization at P114 may facilitate population of a partially unfolded intermediate or alternative structure competent for domain swapping, and provide support for a more general role for proline isomerization as a conformational gatekeeper in domain swapping and oligomerization.
Other authorsSee publication -
Real-time Investigation of SV40 Large T-antigen Helicase Activity Using Surface Plasmon Resonance.
Cell Biochem Biophys.
The simian virus 40 (SV40) genome is a model system frequently employed for investigating eukaryotic replication. Large T-antigen (T-ag) is a viral protein responsible for unwinding the SV40 genome and recruiting necessary host factors prior to replication. In addition to duplex unwinding T-ag possesses G-quadruplex DNA helicase activity, the physiological consequence of which is unclear. However, formation of G-quadruplex DNA structures may be involved in genome maintenance and function, and…
The simian virus 40 (SV40) genome is a model system frequently employed for investigating eukaryotic replication. Large T-antigen (T-ag) is a viral protein responsible for unwinding the SV40 genome and recruiting necessary host factors prior to replication. In addition to duplex unwinding T-ag possesses G-quadruplex DNA helicase activity, the physiological consequence of which is unclear. However, formation of G-quadruplex DNA structures may be involved in genome maintenance and function, and helicase activity to resolve these structures may be necessary for efficient replication. We report the first real-time investigation of SV40 T-ag helicase activity using surface plasmon resonance (SPR). In the presence of ATP, T-ag was observed to bind to immobilized single-stranded DNA, forked duplex DNA, and the human telomeric foldover quadruplex DNA sequence. Inhibition of T-ag duplex helicase activity was observable in real-time and the intramolecular quadruplex was unwound.
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⁉️ Did you know that we held our 1st ever Pachamama Ventures Quarterly Investors & Founders Meeting back in March? It was well attended & the…
⁉️ Did you know that we held our 1st ever Pachamama Ventures Quarterly Investors & Founders Meeting back in March? It was well attended & the…
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We're humbled to announce the acquisition of Civilization Ventures portfolio company Fluent BioSciences Inc. by Illumina - our 10th exit in the fund!…
We're humbled to announce the acquisition of Civilization Ventures portfolio company Fluent BioSciences Inc. by Illumina - our 10th exit in the fund!…
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As a child of a parent who struggled with drug addiction, I grew up in a home and community that never explained what was happening. The pervasive…
As a child of a parent who struggled with drug addiction, I grew up in a home and community that never explained what was happening. The pervasive…
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📣 Calling all Rhode Island tech enthusiasts, entrepreneurs, and anyone who cares about making the Ocean State a great place to build a business!…
📣 Calling all Rhode Island tech enthusiasts, entrepreneurs, and anyone who cares about making the Ocean State a great place to build a business!…
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In early April, I woke up to an email that I never expected to receive. I was offered an investment from a venture fund I didn't know, based on an…
In early April, I woke up to an email that I never expected to receive. I was offered an investment from a venture fund I didn't know, based on an…
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🎥 I went to film school. 🎸 I was in a band. 🎶 I managed artists for 11 years...Now I am a financial advisor. 🎤 When I mention that I…
🎥 I went to film school. 🎸 I was in a band. 🎶 I managed artists for 11 years...Now I am a financial advisor. 🎤 When I mention that I…
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As a kid, I wanted to be a talk show host. Now I get to live out that dream as a podcast host. Which is even better because I can do it in my…
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