Isabel Beerman

Baltimore City County, Maryland, United States Contact Info
486 followers 477 connections

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Experience & Education

  • National Institute on Aging (NIA)

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Volunteer Experience

  • Math Tutor

    Boston Partners

    - 1 year

    Education

  • Scientist

    Science Education Outreach Program at Yale University

    - 2 years

    Education

Publications

  • Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

    Cell Stem Cell

    A review of the current understanding of epigenetic regulation of tissue specific stem cell populations during steady state, during aging, and disease. The abstract is posted below:
    Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to…

    A review of the current understanding of epigenetic regulation of tissue specific stem cell populations during steady state, during aging, and disease. The abstract is posted below:
    Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell function, and emerging evidence indicates that epigenetic dysregulation contributes to the altered potential of stem cells during aging. Unlike terminally differentiated cells, the impact of epigenetic dysregulation in stem cells is propagated beyond self; alterations can be heritably transmitted to differentiated progeny, in addition to being perpetuated and amplified within the stem cell pool through self-renewal divisions. This Review focuses on recent studies examining epigenetic regulation of tissue-specific stem cells in homeostasis, aging, and aging-related disease.

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  • Epigenetic regulation of HSC aging

    Exp Cell Res

    An invited review highlighting DNA methylation, histone modifications, and ncRNA changes that are associated with HSC aging. This review also discusses on the possible connection between DNA damage and epigenetic alterations

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  • Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

    Cell Stem Cell

    We demonstrate age-associated DNA damage accumulation is restricted to the hematopoietic stem cell (HSC) compartment, and demonstrate that DNA damage response and repair pathways are attenuated in quiescent HSCs using genome-wide transcription analysis. Though adult HSCs are almost exclusively quiescent, we show that HSCs- regardless of age- have the capacity to recognize and repair accumulated strand breaks when driven into cycle.

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  • Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

    Cell Stem Cell

    This was the first genome-wide analysis of age-associated epigenetic alterations in hematopoietic stem cells (HSCs). We demonstrate that contrary to global hypomethylation associated with aging somatic cells, HSCs increase their global methylation. We further demonstrate that these epigenetic alterations are driven by the proliferative history of the stem cells, and defined concerted DNA methylation alterations that occur in both physiologic aging and induced proliferation.

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  • DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

    Molecular Cell

  • Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

    Proc Natl Acad Sci

  • Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

    Proceedings of the National Academy of Sciences

  • Please see other publications on my Google scholar page

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