Karius

We’re thrilled to announce that the #KariusTest has been granted designation as a Breakthrough Device from the FDA for use in the diagnosis and management of immunocompromised patients with suspected lung infections, including lower respiratory infection and pneumonia. “The Karius Test is commercially available nationwide as a laboratory developed test. We are seeking FDA marketing authorization of the Karius Test for lung infections in immunocompromised patients because improved diagnostic tests are urgently needed for these patients,” said Brad Perkins, our Chief Medical Officer. As noted in the American Thoracic Society Workshop Report for Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria, lung infections have high morbidity and mortality in immunocompromised patients, which is why advances in technologies like metagenomic sequencing used for the Karius Test are vital in improving the diagnosis and treatment of these patients.” New data on the Karius Test and cost-effectiveness in pneumonia will be presented at #ATS2024. https://hubs.li/Q02xnTnm0 #FDA #pneumonia #infectiousdiseases #metagenomic #breakthroughdevice

A retrospective cohort study from Prisma Health – Midlands Richland Campus Hospital showing the use of The Karius Test resulted in high clinical utility in most cases. Positive tests were associated with high diagnostic utility. Consultation with the Karius medical director is recommended to maximize utility. https://hubs.li/Q02GY0DN0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing

We look forward to exhibiting at Infectious Disease Association of California's 38th Annual Southern California Symposium. This year's symposium focuses on infective endocarditis. If you're attending, stop by the Karius table to learn more about the Karius Test, meet our local reps, and collect one of our endocarditis lapel pins! #kariustest #infectiousdisease #endocarditis

In complex osteoarticular infections, The Karius Test enhanced diagnostic accuracy by 11.6%, proving especially beneficial in diagnosing native vertebral osteomyelitis and infections with concurrent endocarditis or endovascular complications. These findings underscore the utility of The Karius Test in the diagnostic workflow for challenging osteoarticular infections, potentially altering clinical management for a significant subset of patients. https://hubs.li/Q02G1CPT0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #steoarticularinfection #vertebralosteomyelitis #osteomyelitis #osteoarticular

The Karius Test detects not only the microbial species causing the infection but also reports on some of the most critical resistance mechanisms as demonstrated by this case report. https://hubs.li/Q02FdGHY0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #abscess #necrotizingpneumonia #pneumonia #aneurysm #sepsis #communityacquiredmrsa #mrsa #pediatrics

A case of vascular graft infection where The Karius Test confirmed an infection with Histoplasma capsulatum while multiple bacterial and fungal/mycobacterial blood cultures were negative. https://hubs.ly/Q02F1W-c0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #disseminatedHistoplasmosis #histoplasmosis #vasculargraftinfection #VGI #aorticgraft #graft

This review highlights mcfDNA-based diagnostics like The Karius Test as of particular interest in diagnosing the cause of an invasive fungal infection. https://hubs.li/Q02DJmpH0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #aspergillosis #fungalinfection #IFI #rhinosinusitis #invasive #mucormycosis #pediatric

A case report where The Karius Test diagnosed Histoplasma capsulatum as the cause of a mitral valve endocarditis while the initial blood cultures were all negative. https://hubs.li/Q02Dzpvh0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #endocarditis #histoplasmacapsulatum #histoplasmosis #mitralvalve #cardiology #generalmedicine #internalmedicine

A review highlighting the performance of The Karius Test in diagnosis of periprosthetic joint infections and its ability to detect polymicrobial infections or identify microorganisms that do not grow in culture. https://hubs.li/Q02DsrxD0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #pji #periprosthetic

A recent review highlighting the potential of plasma-based mcfDNA-based metagenomics like The Karius Test to non-invasively diagnose C. bantiana brain abscess. https://hubs.li/Q02Dczbk0 #ngs #microbiologicaldiagnosis #cellfreeDNA #cfDNA #mcfDNA #microbialcellfreeDNA #diagnostics #clinicaldiagnostics #infectiousdisease #infection #metagenomicsequencing #moleculardiagnosis #diagnosis #metagenomics #liquidbiopsy #infections #healthcareinnovation #microbiology #noninvasive #rapiddiagnosis #rapidtest #sequencing #fungi #melanizedfungus #brainabscess #abscess #phaeohyphomycosis #cladophialophora