Genetic Engineering & Biotechnology News

Personalized Meds Sector Should Look to Microfluidics for Purification Instead of using current tech, personalized medicine developers should use systems designed to process smaller volumes for downstream processing.

Techno-Economic Analyses Link Process Parameters to Financial Metrics As shown in this article, many steps in bioprocessing need improvements, and tools exist to take on some of those challenges. As bioprocessing jumps one hurdle, more will appear, often because of improvements in technology or evolving societal needs. It’s just the nature of the industry.

Rentschler Biopharma’s New Production Line in Massachusetts Now Fully Operational One major project is already underway at the new Rentschler Biopharma site, with other projects in the pipeline, according to the company.

Respiratory Bacteria "Talk" Immune System into Tolerating Infection Researchers at The University of Queensland identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness. The team’s in vitro studies in cultured human respiratory epithelia showed how infections with H. influenzae can induce tolerance and dampen immune responses.

Harvard Scientists Publish Details of Enzymatic RNA Synthesis Tech Commercialized by EnPlusOne Scientists at the Wyss Institute at Harvard University at Harvard University and Harvard Medical School have published details of a technology for synthesizing single-stranded RNA using water and enzymes that is being commercialized by RNA synthesis company EnPlusOne Biosciences.

Deep Dive into Brain's Molecular Structures Affected by Alzheimer's Disease Using cryo-electron tomography, guided by fluorescence microscopy, scientists say they explored deep inside an Alzheimer’s disease donor brain. The findings revealed the molecular structure of tau in tissue, how amyloids are arranged, and new molecular structures entangled within this pathology in the brain. The research was led by scientists at the University of Leeds in collaboration with scientists at Amsterdam UMC, ZEISS Microscopy, and the University of Cambridge. https://lnkd.in/ejdzS86A

Adapting a Replication-Competent AAV Assay for Commercial Manufacturing In this tutorial Oxana Tsygankova, PhD, Lana Sweet (Mogilyansky), Dana Cipriano, M.S., and Brian Tomkowicz, PhD, from SK pharmteco describe technology for monitoring and mitigating rcAAV formation that can enhance the safety profiles of gene therapy vectors.

Making Analytical Tools More Accessible to Bioprocessors It's important for process specialists to not only have the data in real-time, but also to have the interpretation of that data immediately. As a tool developer, “our mission is to make analytical tools easily accessible so the bioprocess scientists developing processes can perform key analysis themselves,” rather than having to hand off analyses to other labs, Graziella Piras, a senior director at 908 Devices, tells GEN.

Nirrin Launches Atlas for At-Line Analysis at the Point of Sampling The existing bioprocess analytical workflow is full of blind spots. Therapeutic development is an iterative and complicated process requiring analysis at each process step and suffers from either no data or slow data collection. Nirrin’s Atlas system enables simultaneous analysis of buffer excipients, such as surfactants, amino acids, and high concentration proteins.

Keeping Bioprocessing Clean Although “achieving complete sterilization of complex equipment and operational procedures is difficult,” various methods can reduce this challenge.