Form Bio

Empty capsids are AAV particles that lack genetic material, posing immunological risks without offering therapeutic benefits. Despite the absence of formal FDA guidance on upper limits for residual empty capsids in AAV-based therapies, the gene therapy field advises including total capsid titre in FDA applications for safety at high vector doses. Explore the prevailing causes and risks of empty capsids and discover how AI can enhance the design and manufacturability of AAV-based gene therapies by predicting and reducing truncation. Read along to learn more about AI’s potential in unlocking progress in the field of gene therapy. #GeneTherapy #AAV #AI

Did you know that AAV vectors can achieve long-term expression of therapeutic genes, especially in non-dividing cells? This minimizes the need for repeated treatments. With their broad tropism, AAV vectors can target a wide range of tissues and organs effectively. Moreover, AAV vectors ensure persistent gene expression through stable integration at specific genomic sites. Discover how AAV is transforming gene therapy and explore its versatility, major challenges, and key benefits with insights from Form's CSO, Claire Aldridge. Learn more: https://hubs.li/Q02G46Bc0 #GeneTherapy #AAV #VectorDesign #GeneExpression

Join Brandi Cantarel, PhD, VP of Bioinformatics at Form Bio, as she unveils the drivers behind her passion for bioinformatics after 20 years in the field. Discover what excites her about Form Bio and her vision for accelerating scientific and clinical advancements. "My real hope for Form Bio is that it can help scientists and clinicians do their science faster and better." #Innovation #Bioinformatics #Teamwork #Science

Can you guess it?

“Getting AAV-based gene therapies to the clinic requires speed and collaboration among many different parties. But it’s become clear that speed and collaboration are being held back by the lack of a common language and practices in dealing with AAV vectors,” said Claire Aldridge, Ph.D, chief strategy officer for Form Bio. “We see working with our partners at PacBio and bringing together leaders across academia and industry as a critical need in helping AAV-based gene therapies reach their fullest potential faster,” she added. https://hubs.li/Q02FgJwB0 #AAV #bestpractices #genetherapy #HiFisequencing #productcharacterization

Join Linda (Ge) Murray, CFO of Form Bio, to learn why our company's mission resonates deeply and how our team is uniquely positioned to make a significant impact in the biotech space. Explore the passion behind our work and the audacity driving us to tackle the seemingly impossible. #Innovation #Biotech #Teamwork #Impact #Careers

Join Form Bio and PacBio for a relaxing evening al fresco in South San Francisco. Thursday, July 18th |  5:30 - 8:30 PM Enjoy a variety of artisan beverages and seasonal appetizers as you connect with industry peers and discuss the future of gene therapy. Space is limited, request an invite. Complete the form to request an invitation: https://lnkd.in/gBm8D_93 #Networking #AI

🚀 Our Monthly Newsletter is Here! 🧬 Here’s all that's new with Form Bio: 🔬 Announcing the New AAV Resource Hub: Designed for AAV-based gene therapy researchers and professionals to address industry challenges, such as optimizing AAV construct design and ensuring manufacturing quality. 🧬 Request an Invite to an Exclusive Gene Therapy Leadership Reception: Co-hosted with PacBio, join us to network with your peers al fresco in South San Francisco July 18th. 🎥 Watch the Alliance for Regenerative Medicine Advanced Manufacturing Workshop On Demand: Anusha Sriraman, Ph.D. of Form Bio, shares how AI/ML models can optimize and de-risk vector designs, improving the packaging and manufacturability of gene therapy vectors. Click the link below to read the full newsletter. #GeneTherapy #AAV #AI #Newsletter

Form Bio and PacBio have joined forces to advance AAV design and analysis best practices! We've formed a new AAV Working Group, composed of top experts from industry and academia, to drive improvements in vector design and product quality forward. 🌟 AAV vectors are revolutionizing gene therapy with their non-pathogenic nature, but manufacturing challenges like low yield and quality keep costs high and limit accessibility. Long-read sequencing is the gold standard for assessing AAV vectors, but the lack of industry-wide standardization has created hurdles for regulatory agencies. Form Bio and PacBio have teamed up to bring the gene therapy community a dedicated AAV Resource Hub—a toolbox of resources to help unify researchers and advance the development of more effective and safer therapeutics.🔬🧬 https://hubs.li/Q02DzmXY0 #AAV #bestpractices #genetherapy #hifisequencing #AAVvectors

Beibei Chen, Ph.D., a Machine Learning Engineer at Form Bio, shares her passion for coding and how her work is making a global impact. Discover why BeiBei believes Form Bio's team is uniquely special and what drives her to push the boundaries of innovation every day. #Innovation #Teamwork #ML #Bioinformatics #Careers