Calico Life Sciences

Model organisms like yeast are helping Calico scientists like Reinhard identify molecular changes that cause aging and the downstream age-associated events that lead to cellular decline. Learn more about how Calico’s culture of curiosity-driven research creates countless possibilities for Reinhard and his colleagues to develop as researchers and further scientific knowledge: https://lnkd.in/gdFFYBHb #ExploreWithUs #ScienceCareers

Aging cells cause diseases that impact everything from brain health to immunity. Calico scientists studying the roundworm C. elegans have mapped gene activity in every cell type of this tiny worm, revealing that aging is an organized process, with each cell type following its own aging path. Learn how we’re building cell atlases to understand how these cellular changes cause disease in our latest story. https://lnkd.in/g_yekMEd #scienceofaging

In our newest Calico Story: Recent research published in Nature Genetics expands the body of knowledge about the relationship between aging and blood cell mutations and could help pave the way to early disease detection and new diagnostics in the future. Read more and explore other stories about Calico’s research: https://lnkd.in/gZWVtGtq #CalicoStories #AgingResearch #AgingScience

We are honored to share that fosigotifator (ABBV-CLS-7262) has been selected for the FDA’s START Pilot Program, an innovative new initiative which aims to accelerate the development of novel drug and biological products for rare diseases. Fosigotifator is being developed by Calico and AbbVie as a potential treatment for Vanishing White Matter (VWM) disease, an ultra-rare genetic condition that causes the deterioration of white matter in the brain and permanently affects the transmission of nerve signals to the rest of the body. Currently, there is no cure or approved treatments for VWM disease. VWM disease is caused by genetic variations affecting eIF2B, a protein complex essential for stress response regulation in cells. Calico’s foundational research into eIF2B and the Integrated Stress Response, along with our productive partnership with AbbVie, have played a crucial role in advancing this new drug candidate. We look forward to working closely with the FDA to accelerate the development of fosigotifator in service of bringing hope to those living with this devastating rare disease. Read more in our press release: https://loom.ly/b_A1Amc

For scientists at Calico, tackling the toughest questions about aging starts with intellectual freedom, curiosity and a spirit of teamwork that welcomes new and diverse perspectives. Learn how Calico’s culture and core values enable Xiumin and her colleagues to push the boundaries of research today in order to help devise clinical interventions that might help people lead longer, healthier lives tomorrow. https://lnkd.in/gG3reMZa #ExploreWithUs #ScienceCareers

We're happy to see research from our collaboration with the Wellcome Sanger Institute & University of Cambridge published in Nature Genetics today! Our team identified new genetic drivers for age-related mutations in blood that may have implications for how we diagnose & treat blood cancers and related myeloproliferative diseases in the future.

We are excited to announce the extension of Calico’s partnership with the Broad Institute of MIT and Harvard, with an added focus on age-related neurodegeneration. This nearly decade-long partnership is now extended until September 2029, allowing us to continue collaboratively exploring the biology and genetics of aging, as well as early-stage drug discovery. Together, we are increasing scientific understanding of aging and age-related diseases, leveraging our combined expertise to drive impactful research and advance new therapeutic development to help people lead longer and healthier lives. We look forward to building on our successful collaboration in the years to come. Read more: https://lnkd.in/gscRPeMQ #aging

Why study aging? Maintaining health into old age has become a new and urgent frontier for modern medicine. At Calico, our mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging—and use that knowledge to devise interventions that enable people to lead longer and healthier lives. Explore some of the key data that underscore the importance of this effort, and how Calico scientists and technologists are answering the call.  #scienceofaging #healthspan

From discovering the double helix in 1953 to mapping the human genome in 2003, rapid advancements in our understanding of DNA help answer even the most complex biological questions. Today, innovative machine learning models help decode critical disease insights from DNA. For #NationalDNADay, Calico Principal Investigator David Kelley, PhD, shares Calico’s approach to building a machine learning toolkit that maps genetic associations with aging related diseases to the mechanisms of aging: #genomics #DNA

Unlocking the mysteries of aging requires collaboration and open dialogue. At Calico Life Sciences, we believe in the power of sharing scientific research with the community to propel aging research forward. By fostering a culture of knowledge exchange, we collectively drive innovation, accelerate discoveries, and pave the way for a healthier future. Explore Calico’s peer-reviewed publications at: https://lnkd.in/e7fmrvaB