Allen Institute for Neural Dynamics

We're hiring! Check out our open positions and be a part of an innovative team studying how brain circuitry and activity drive behavior, learning and decision-making: https://lnkd.in/gdtgxhQj #NowHiring #NeuroscienceJobs

Meet one of the teams behind our #TeamScience - the electrophysiology group! The Electrophysiology (ephys) group is combining cutting-edge tools for recording electrical activity, such as Neuropixels probes, with reagents for identifying and perturbing specific neuronal cell types in living brains. Their current focus is on improving the reliability and throughput of extracellular electrophysiology experiments. https://lnkd.in/gy9xz7n8

🚀 Exciting Opportunity Alert! 🚀 Are you passionate about #Neuroscience and #PredictiveCoding? 🧠🔍 We invite all neuroscientists to contribute to an open science experiment co-organized by the OpenScope program Allen Institute, Michael Berry, Colleen Gillon, Konrad Kording, and the CCN workshop! 🤝🌐 We're exploring predictive coding and need YOUR expertise to review the computational and experimental literature. 📚 💡 Predictive coding is a leading theory of cortical function, with significant implications for perception, cognition, learning, and overall brain function. 🧠✨ ❓ Central question: What mechanisms underlie the subtraction of predictions from sensory input data? 📄 We've created a Google Doc for collaborative brainstorming on a future perspective piece. Dive in, share your insights, and help shape the future of neuroscience! 📝🌟 https://lnkd.in/gXSQmbFz 🔗 The Allen Institute’s OpenScope Program is READY to perform the proposed experiment on the @alleninstitute pipelines. 🌐🚀 🌍 This is #ScienceInTheOpen! Your contributions will be credited, and you’ll be part of an innovative community pushing the boundaries of knowledge. 🌟📈 We will meet in Boston on August 8th as part of the CCN workshop to discuss new experiments that the field needs to move forward on Predictive Coding. Attend this event. https://lnkd.in/gJAzV7hF 📊 Datasets from this endeavor will be made immediately openly accessible to the entire scientific community for analysis. 📊🌐 💬 Questions? DM us or comment below! Let's actually DO science in the Open 🔍 #OpenScience #CollaborativeResearch #CCN #Neuroscience

Check out my first ever co-authorship on a publication I had the pleasure of contributing to at the Allen Institute last summer! Thank you Carter Peene and Jerome Lecoq for helping me learn so much by working on this fantastic resource. Cheers to Open Science! https://lnkd.in/gyK9EWiP

Thanks to all those that joined us for the OpenScope and Neuropixels technical workshop at the Allen Institute and Nicholas Steinmetz lab. It was a pleasure to host you all. We will do that again next year! Look for our application cycle in early 2025.

Former employees and interns are invited to RE:CONNECT - an open house for Allen Institute alumni! Meet other alumni, learn about our latest research, discover new programs and workshops you can take advantage of, and take home Allen Institute swag. Due to space limitations, this event is for former Allen Institute employees, interns, and current staff only.

In complex environments, animals can adopt diverse strategies to find rewards, but how these approaches engage brain circuits is not well understood. 📺🕹️🐁 By studying how mice trained to perform a visual change detection task, an Allen Institute found differences in activity across cell types, especially the Vip-Sst disinhibitory circuit. Congrats to the study team - Alex Piet, Nick Ponvert, Douglas Ollerenshaw, Marina Garrett, Peter Groblewski, PhD, Shawn Olsen, Christof Koch, and Anton Arkhipov. Out now in Neuron (Cell Press): https://lnkd.in/gJEMePEd

We're hiring! Check out our open positions and be a part of an innovative team studying how brain circuitry and activity drive behavior, learning and decision-making: https://lnkd.in/gdtgxhQj #NowHiring #NeuroscienceJobs

Openscope and Neuropixels technical workshop is happening Allen Institute!

This paper by Alex Piet and Allen Institute team is now officially published: Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex https://lnkd.in/g7hbg6fp Alex and team analyzed the Allen Institute Visual Behavior - Calcium Imaging dataset, where 🐭 perform a change detection task: Mice watch flashing images, and when image identity changes, they lick for reward. BTW, these data are open for all: https://lnkd.in/gM9U_JgR Using a dynamic logistic regression model, Alex found that individual mice use mixtures of a visual comparison strategy and a statistical timing strategy to solve the task. Individual mice tend to settle on a particular strategy and use it consistently in multiple sessions. 2p calcium imaging shows strategy dependent differences in neural activity of Exc, Sst Inh, and Vip Inh cells in the visual cortex in response to both image changes and omissions. That is, a cognitive strategy affects information processing in sensory cortex. The main effect is the increased activation of the Vip-Sst disinhibitory circuit during the visual comparison strategy which facilitates task appropriate responses. This sheds light on how cognitive states alter sensory processing. This study was made possible by the classical BIG Science, OPEN Science, TEAM Science approach at Allen Institute. Many thanks to Alex Piet, Nick Ponvert, Douglas Ollerenshaw, Marina Garrett, Peter Groblewski, PhD, Shawn Olsen, and Christof Koch.