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Massage can alleviate the inflammatory process, help to accelerate recovery, and relieve pain resulting from muscular injuries. In this paper, we combine the idea of mechanotransduction (conversion of mechanical stimulus into electrochemical activity) using grounding in massage to investigate beneficial mechanisms. Grounding massage has been discovered to stabilize the physiology of the body, help reduce pain, inflammation, stress, enhance sleep, increase energy, and blood flow, and enhance well-being by connecting the body with the electrical charges of the Earth. Such effects are systemic and basic, and often quickly evolve. This process can reduce secondary injury, collateral sprouting, and nerve sensitization by modifying inflammatory signaling pathways, resulting in improved damage recovery and pain reduction or prevention. Research shows that grounding, when simultaneously combined with many CAM clinical practices, can offer great potential to improve their effectiveness. The paper aims to explain how massage therapy, combined with geographically and simultaneous earthing, causes a potentially beneficial and properly activated immunomodulatory pathway.

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