Intake of total whole grains and effect on coronary heart disease, stroke, cardiovascular disease, total cancer, all cause mortality, and cause specific mortality. Analysis of low versus high intake and dose-response analysis
High v low analysis | Dose-response analysis | |||||||||
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No of studies | RR* (95% CI) | I2 | P value† | Dose (g/day) | No of studies | RR* (95% CI) | I2 | P value† | ||
Incidence | ||||||||||
Coronary heart disease | 5 | 0.80 (0.74 to 0.87) | 0 | 0.62 | 90 | 5 | 0.84 (0.77 to 0.92) | 34 | 0.20 | |
Stroke | 3 | 0.86 (0.60 to 1.20) | 65 | 0.06 | 90 | 3 | 0.84 (0.59 to 1.20) | 74 | 0.02 | |
Cardiovascular disease | 2 | 0.89 (0.81 to 0.99) | 0 | 0.40 | 90 | 2 | 0.87 (0.78 to 0.97) | 0 | 0.85 | |
Incidence or mortality | ||||||||||
Coronary heart disease | 6 | 0.79 (0.73 to 0.86) | 0 | 0.63 | 90 | 7 | 0.81 (0.75 to 0.87) | 9 | 0.36 | |
Stroke | 5 | 0.87 (0.72 to 1.05) | 32 | 0.21 | 90 | 6 | 0.88 (0.75 to 1.03) | 56 | 0.04 | |
Cardiovascular disease | 9 | 0.84 (0.80 to 0.87) | 0 | 0.48 | 90 | 10 | 0.78 (0.73 to 0.85) | 40 | 0.09 | |
Mortality | ||||||||||
Coronary heart disease | 2 | 0.65 (0.52 to 0.83) | 33 | 0.22 | 90 | 3 | 0.81 (0.74 to 0.89) | 10 | 0.33 | |
Stroke | 2 | 0.85 (0.64 to 1.13) | 0 | 0.99 | 90 | 3 | 0.86 (0.74 to 0.99) | 34 | 0.20 | |
Cardiovascular disease | 7 | 0.81 (0.75 to 0.87) | 37 | 0.15 | 90 | 8 | 0.71 (0.61 to 0.82) | 72 | 0.001 | |
Total cancer | 6 | 0.89 (0.82 to 0.96) | 72 | 0.003 | 90 | 6 | 0.85 (0.80 to 0.91) | 37 | 0.16 | |
All cause | 9 | 0.82 (0.77 to 0.88) | 83 | <0.001 | 90 | 11 | 0.83 (0.77 to 0.90) | 83 | <0.001 | |
Respiratory disease | 4 | 0.81 (0.69 to 0.94) | 63 | 0.05 | 90 | 4 | 0.78 (0.70 to 0.87) | 0 | 0.46 | |
Diabetes | 4 | 0.64 (0.42 to 0.98) | 64 | 0.04 | 90 | 4 | 0.49 (0.23 to 1.05) | 85 | <0.001 | |
Infectious disease | 3 | 0.80 (0.68 to 0.96) | 0 | 0.68 | 90 | 3 | 0.74 (0.56 to 0.96) | 0 | 0.85 | |
Nervous system disease | 2 | 1.13 (0.89 to 1.43) | 29 | 0.24 | 90 | 2 | 1.15 (0.66 to 2.02) | 79 | 0.03 | |
Non-cardiovascular, non-cancer causes | 5 | 0.79 (0.69 to 0.92) | 86 | <0.001 | 90 | 5 | 0.78 (0.75 to 0.82) | 0 | 0.99 |
*RR<1 favours those with higher intake
†P for heterogeneity.