U.S. immigration officers don't care about what you did before coming to the US (unless it's something illegal), and they practically care only about what you are going to do in the US.
In your case, it is of no concern. The agent would probably assume that you transited in the Netherlands, and CBP agents couldn't care less about your original destinationairport (unless it's Yemen or Syria, of course). They see, for example, lots of Filipinos coming from Tokyo, or Indians coming from Hong Kong, and would just assume they've got an itinerary with a transit. So, no, this isn't very unfamiliar to them.