In short, I do not want "MsMpEng.exe" to be running in the background. I have tried the Group Policy method, but when I rebooted, that setting was set back to "Not configured". I have tried the Registry method, but HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender\DisableAntiSpyware was automatically deleted after reboot.
Do Microsoft actively preventing such methods, and do not allow any method to disable it at all? I think I could try more dramatic methods like trying to delete the Windows Defender directory after booting into Safe Mode, but if possible, I want a cleaner method.
PS: In the TaskManager, I right-clicked "MsMpEng.exe", and then chose "Open file location". I opened the file's properties, and in the Security -> Advanced, I changed the file's owner from TrustedInstaller to my account. Then I removed all inherited permissions and made my own account the only account that can access the file. I rebooted the OS, and Windows Defender failed to start automatically, because it could not execute "MsMpEng.exe". I went up to its parent directories, and delete all of the Defender's directories. It seems that Windows is starting/running fine after that.