The best way would probably be to make a link after you move it. A lot of applications search for your profile folder under C:\users and moving it somewhere without making an association to it will give you a headache. After moving it over to U:\<username> create a directory symbolic link to it:

MKLINK /d C:\Users\<username> U:\<username>

The best way would probably be to make a link after you move it. A lot of applications search for your profile folder under C:\users and moving it somewhere without making an association to it will give you a headache. After moving it over to U:\<username> create a directory symbolic link to it:

MKLINK /J C:\Users\ U: