Yes, you can use it with a closed lid with no problems,problems; I use it like this every day. I dontdon't know what type of work you do, but if youyou're stressing hwthe hardware a lot itsit's good to lift up little bitthe tail of zenbookthe Zenbook a little bit (about 1 inch/2cm) to create space for air flowairflow. Its not needneeded,but i but I think that can extend life of my machine. :)