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  • Welcome to Super User. Please see How to Ask a Good Question then edit your question. Pay particular attention to the section titled Search, and research
    – Blindspots
    Commented May 5, 2023 at 20:39
  • Plesk can fairly heavily modify the linux on which it runs. Can you give us your plesk version and os with version please? It might also be worth tagging the question with postfix. The other standard ports for mail are 587 and 465, but you'll need to modify both main.cf and master.cf to get the services and security lined up correctly.
    – Greig
    Commented May 6, 2023 at 16:23
  • 1
    Which ISP is blocking the ports – your home, or the VPS host? Commented May 6, 2023 at 19:19